ReviewFrontiers in veterinary science2025
Evidence of osteoarthritis disease modification with a Sn-117m microparticle device: a review and validation in mammalian models.
Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pilot study demonstrating safety and efficacy of intravenous allogeneic uterine-derived mesenchymal stromal cell therapy in cats with naturally occurring osteoarthritis.Frontiers in veterinary science · 2026Trial
- Radiation in Veterinary Practice: Paradigm Shift Toward Precision and Curative Approaches.Life (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a progressive joint disorder affecting mammals as well as many non-mammalian animals, characterized by cartilage degradation and synovial inflammation, yet current treatments focus solely on symptom relief rather than disease modification. Radiosynoviorthesis (RSO) using commercially available homogeneous Sn-117m microparticles (HTM) (Synovetin OA®, Exubrion Therapeutics, Inc.) injected into the arthritic joint space targets synovitis-a critical driver of OA progression-offering a novel therapeutic approach. This review collates preclinical and clinical evidence demonstrating HTM's potential to alter OA's natural course in mammals. We explore OA pathogenesis, emphasizing synovitis, macrophage activity, and the inflammatory cycle, alongside RSO's historical use and Sn-117m's mechanism: low-energy electrons targeting the inflamed synovium. Preclinical studies in male Lewis rats with meniscal tear-induced OA revealed reductions in synovial inflammation, cartilage damage, and osteophyte formation, suggesting a disease-modifying effect. Clinical trials in dogs with elbow OA further substantiate these findings: a Grade 1 & 2 OA study showed durable lameness improvement over 12 months-long after Sn-117m's 13.9-day half-life (t
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.