ArticleFrontiers in veterinary science2025
Integrated 16S rDNA-Seq and metabolomics reveal seasonal dynamics of gut microbial-SCFA-immune crosstalk in diarrheic calves.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Article
- Plasma Zonulin as a Biomarker of Divergent Channels Latency in Systemic Lupus Erythematosus?Healthcare (Basel, Switzerland) · 2026Article
- Effect of different dietary regimes on gut microbiota in water buffalo calves during the preweaning period.BMC microbiology · 2026Article
- Article
- Effects of anVeterinary sciences · 2026Article
- Pathogen Detection and Analysis of Non-Infectious Factors in Calf Diarrhea at a Large-Scale Dairy Farm in Wuwei City.Veterinary sciences · 2025Article
- Dietary Proline Supplementation Promotes Growth and Development in Weaned Foals by Modulating Gut Microbial Amino Acid Metabolism.Microorganisms · 2025Article
- BCAA supplementation enhances milk fat synthesis in Yili mares and promotes foal growth through remodeling of intestinal amino acid metabolism.Frontiers in microbiology · 2025Article
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Abstract
Introduction: Neonatal calf diarrhea incidence varies seasonally, increasing during climatic fluctuations. This study investigated body weight and size, immune function, intestinal permeability, rectal microbiota, and short-chain fatty acid (SCFA) levels in diarrheal and healthy lactating calves across seasons. Methods: Ten lactating healthy and ten diarrhea calves were selected in each season, blood and rectal contents samples were collected. Serum immunity, cytokines, and intestinal permeability markers were measured using kits. Rectal microbiota composition was analyzed via 16S rDNA amplicon sequencing, and SCFA profiles of rectal contents were characterized using targeted metabolomics. Results: Significantly higher levels of interleukin-1β (IL-1β), endotoxin (ET), and diamine oxidase (DAO) and lower levels of interleukin-10 (IL-10), immunoglobulin (IgA and IgG) levels were observed in diarrheic calves compared to those of healthy controls across all four seasons. Acetate and valeric acid concentrations were significantly lower in diarrheic calves in summer, autumn, and winter. In addition, diarrheic calves exhibited significantly reduced alpha diversity compared to than that of healthy controls, as indicated by lower Chao1, Observed_features, and Shannon indices. The relative abundances of Discussion: In conclusion, seasonal factors have an influence on the indicators related to diarrhea in calves. Diarrheic lactating calves showed the characteristics of reduced immunity, increased inflammatory response, reduced rectal microbial diversity, and altered microbiota profiles and SCFA content, and these alterations were closely related to the occurrence of diarrhea in calves.
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