Evidence map›Paper›PMID 40717856›Full record

ArticleHeart rhythm O22025

Automatic measurement of short-term variability of repolarization captures modulation by pacing on human electrograms.

Cheyenne S L Chiu, Vera Loen, Alfonso Aranda Hernandez, Agnieszka Smoczyńska, David J Sprenkeler, Anton E Tuinenburg, Coert O S Scheerder, Paul J DeGroot, Marc A Vos, Mathias Meine

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In one paragraph

Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheyenne S L ChiuDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Vera LoenDepartment of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Alfonso Aranda HernandezCardiac Rhythm Management, Medtronic, Mounds View, Minnesota.
Agnieszka SmoczyńskaDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
David J SprenkelerDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Anton E TuinenburgDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Coert O S ScheerderCardiac Rhythm Management, Medtronic Bakken Research Center, Maastricht, the Netherlands.
Paul J DeGrootCardiac Rhythm Management, Medtronic, Mounds View, Minnesota.
Marc A VosDepartment of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Mathias MeineDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Short-term variability of repolarization (STV) increases prior to ventricular arrhythmias in both humans and animal models, making it a promising tool for real-time arrhythmic risk monitoring. Objective: An automatic STV measurement algorithm was developed for intracardiac electrograms (EGMs) to enable integration into cardiac devices. This method previously demonstrated high accuracy in predicting life-threatening ventricular arrhythmias in animals. This study compared the performance of the automatic method to the gold standard on EGMs in humans. Methods: EGM signals were recorded in 14 patients with a dual-chamber implantable cardioverter-defibrillator during de novo implantation (n = 5) or replacement (n = 9) procedures. Recordings were obtained in sinus rhythm (SR), atrial pacing at 80 beats/min, and dual-chamber pacing at 80 beats/min. STV was determined on the EGM from the activation recovery interval with the automatic method (STV-ARI Results: STV-ARI Conclusion: The novel automatic STV measurement method accurately reflects pacing-induced changes, comparable to the gold standard. Future integration of this technique in implantable cardioverter-defibrillators could furnish continuous monitoring of arrhythmic risk and initiate preventive strategies.

Indexed as

Automatic measurementElectrogramImplantable cardioverter-defibrillatorPacingShort-term variability of repolarizationVentricular arrhythmias

Identifiers

PMID40717856
PMCPMC12287953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.