ArticleSAGE open medical case reports2025
Case series demonstrating the effectiveness of Zn supplements in adults with hypophosphatasia who were overlooked for a long time.
Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During routine medical examinations, we incidentally diagnosed 11 individuals with hypophosphatasia, which is a condition that has previously gone unrecognized. Six patients also had low levels of serum Zn. Supplemental Zn treatment was effective in controlling the symptoms of hypophosphatasia in all patients. One patient complained of muscle pain and twitching after starting Zn supplement treatment temporarily. The subjected three patients in whom Zn supplements were effective showed improvements in bone mineral density and general malaise. Zn supplements might be useful for controlling symptoms in patients with hypophosphatasia who have mild symptoms.
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