Evidence map›Paper›PMID 40717760›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2025

Relationship Between Thiopurine S-Methyltransferase Genotype and Phenotype in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia.

Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Johanne Groothuismink, Marieke J H Coenen, Rawleigh Howe, Teferra Abula

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Awol Mekonnen AliDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences (AMA, TA), Addis Ababa University, Addis Ababa, Ethiopia.
Haileyesus AdamDepartment of Pediatrics and Child Health, School of Medicine, College of Health Sciences (HA, DA), Addis Ababa University, Addis Ababa, Ethiopia.
Daniel HailuDepartment of Pediatrics and Child Health, School of Medicine, College of Health Sciences (HA, DA), Addis Ababa University, Addis Ababa, Ethiopia.
Johanne GroothuisminkDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center (JG, MJH), Nijmegen, The Netherlands.
Marieke J H CoenenDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center (JG, MJH), Nijmegen, The Netherlands.
Rawleigh HoweArmauer Hansen Research Institute (RH), Addis Ababa, Ethiopia.
Teferra AbulaDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences (AMA, TA), Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThiopurine S-methyltransferase (TPMT) is a cytosolic transmethylase enzyme that catalyzes the S-methylation of thiopurine drugs, the mainstay of acute lymphoblastic leukemia treatment. TPMT enzyme activity shows interindividual variability, which can partly be explained by genetic variants in the

methodsIn the present study, 73 on treatment and 32 treatment completed patients were included. TPMT activity was measured in whole blood of the participant by HPLC. The enzyme activity was expressed both in nmol6MTG/gHb/h and mU/L. The 3 most common variants in the

resultsOnly 2 patients carried the *3C variant (719A>C) (both heterozygous), no other variants were detected. In the treatment group, TPMT activity (nmol6MTG/gHb/h) was significantly higher than the treatment completed group (32 vs 25.55, p = 0.018). In the treatment group TPMT activity (nmol6MTG/gHb/h) was significantly higher in individuals with Hb < 12 g/dL compared with individuals with Hb ≥ 12 g/dL (34.05 vs 27, p = 0.037).

conclusionsThis study showed that the commonly genotyped variants in

Indexed as

6-mercaptopurineacute lymphoblastic leukemiagenotypephenotypethiopurine S-methyltransferase

Identifiers

PMID40717760
PMCPMC12288558

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