ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2025
Retrospective Evaluation of Empiric Vancomycin Therapy for Infectious Workups in Relation to Methicillin-Resistant
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Antibiotic Stewardship Quality Improvement Project for Neonatal Sepsis in a Tertiary NICU in Lima, Peru.Pediatric quality & safetyArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study evaluated empiric antibiotic prescribing patterns in relation to methicillin-resistant
methodsThis was a retrospective study of infants admitted to the neonatal intensive care unit (NICU) from December 1, 2022, to May 31, 2023. Infants at least 3 days old who received antibiotics for an infectious workup were included. The prevalence of risk factors for MRSA, including low birth weight, prematurity, outborn status, length of stay, parenteral nutrition, presence of indwelling lines, and history of MRSA-positive blood culture or colonization, was compared between patients who received vancomycin empirically or an alternative agent.
resultsA total of 143 blood cultures were obtained from 95 patients who received antibiotics for an infectious workup during the study period. Group 1 received vancomycin and included 51 (36%) blood cultures. Group 2 received an alternative agent and included 92 (64%) blood cultures. Patients in group 1 had higher rates of every MRSA risk factor included in this study, except for patients who were outborn. Group 1 also averaged a higher total number of MRSA risk factors per patient than group 2 (4.88 vs 2.53; p < 0.001).
conclusionThis institution uses MRSA risk factors to determine empiric antimicrobial therapy in suspected LOS. Further studies are needed to determine the relationship between the studied risk factors and incidence of MRSA infection.
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