Evidence map›Paper›PMID 40717735›Full record

ArticleAIMS neuroscience2025

Enhancing cognition and well-being by treating the malocclusion unilateral posterior crossbite: preliminary evidence by a single case study.

Laura Mandolesi, Noemi Passarello, Eillyn Leiva Ramirez, Deny Menghini, Patrizia Turriziani, Teresa Vallelonga, Francesco Aristei, Angela Galeotti, Stefano Vicari, Vito Crincoli and 1 more

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In one paragraph

Article in AIMS neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura MandolesiGeneral and Experimental Psychology Laboratory, Department of Humanities, University of Naples "Federico" II, Naples, Italy.
Noemi PassarelloGeneral and Experimental Psychology Laboratory, Department of Humanities, University of Naples "Federico" II, Naples, Italy.
Eillyn Leiva RamirezDepartment of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.
Deny MenghiniChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Patrizia TurrizianiNeuropsychology Lab, Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy.
Teresa VallelongaOrthodontic Private practice, Koelliker Hospital and Nursing Home, Turin, Italy.
Francesco AristeiDentistry Unit, Management Innovations, Diagnostics and Clinical Pathways, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Angela GaleottiDentistry Unit, Management Innovations, Diagnostics and Clinical Pathways, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefano VicariChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Vito CrincoliDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy.
Maria Grazia PiancinoDepartment of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientific investigations have increasingly revealed the intricate connection between masticatory function and cognitive functioning, as well as psychological well-being. Addressing malocclusions, such as the common unilateral posterior crossbite, during early developmental stages, emerges as an effective strategy for gaining health. This study aims to evaluate the efficacy of treating unilateral posterior crossbite by utilizing a function generating bite (FGB) appliance in a 12-year-old child, focusing on its impact on specific cognitive domains. Through meticulous pre- and post-treatment assessments, encompassing global cognitive activity (Colored Progressive Matrices), verbal and spatial working memory (Digit Span and Corsi Block-Tapping Test), and graphic fluency (modified Five Points Test), this research aims to elucidate the cognitive benefits associated with FGB treatment. Results unveil that a mere seven-month application of FGB effectively rectified the malocclusion while concurrently yielding notable improvements in the cognitive abilities under scrutiny. Additionally, post-treatment observations revealed enhanced well-being and sleep quality, further emphasizing the multifaceted benefits of such interventions. Although this study presents findings from a singular case, it serves as a catalyst for further exploration into the intricate interplay between masticatory function and cognitive performance. Such endeavors are vital for advancing holistic healthcare practices that integrate dental care with cognitive and psychological considerations, thereby fostering comprehensive well-being and optimal development.

Indexed as

childrengraphic fluencymasticationmemoryspatial abilities

Identifiers

PMID40717735
PMCPMC12287644

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.