ArticleRespirology case reports2025
Central Airway Recanalisation Using Dual Debulking With Para-Toluenesulfonamide (CLEAR-DUAL-PTS).
Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Intratumoral Para-Toluenesulfonamide (PTS) Injection for Recurrent Hepatocellular Carcinoma Adjacent to the Heart: A Case Report.Journal of hepatocellular carcinoma · 2026Article
- Central Airway Recanalisation Using Dual Debulking With Para-Toluenesulfonamide (CLEAR-DUAL-PTS).Respirology case reports · 2025Article
- Therapeutic Bronchoscopic Intratumoral Injection in Lung Cancer: Current Advances, Challenges, and Opportunities for Resource-Limited Settings.Open respiratory archivesReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary adenoid cystic carcinoma (PACC) is a rare salivary gland-type malignancy of the tracheobronchial tree, accounting for 0.04%-0.2% of primary lung cancers. It may cause severe malignant airway obstruction (SMAO), necessitating urgent intervention. Surgical resection remains the primary treatment, but inoperability or patient preference may require alternative strategies. We report a case of a 57-year-old non-smoking female with PACC-SMAO who presented with total left lung collapse due to left main bronchus (LMB) involvement. She declined surgery and underwent bronchoscopic dual debulking combining electrocautery snaring with repeated intratumoural para-toluenesulfonamide (PTS) injections. The intervention safely reduced tumour burden, restored airway patency, and significantly improved clinical and radiological outcomes without adverse events. Our case underscores PTS as a promising adjunct therapy for inoperable PACC-SMAO, warranting further investigation into its long-term efficacy and optimal dosing. This innovative approach may significantly redefine palliative care options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.