Evidence map›Paper›PMID 40717686›Full record

ReviewEuropean journal of haematology2025

Contraception in Myeloproliferative Neoplasms: A Pharmacological Review.

Awni Alshurafa, Maria Benkhadra, Anas M Babiker, Wafa M Mohammed, Mohamed A Yassin

Abstract readReview
In one paragraph

Review in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Awni AlshurafaHematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0002-4454-5307
Maria BenkhadraDepartment of Pharmacy, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Anas M BabikerHematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0001-7374-3452
Wafa M MohammedHematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Mohamed A YassinHematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

Funding

Qatar National Library
6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs) are chronic hematologic disorders characterized by clonal proliferation of myeloid lineage cells, commonly driven by JAK2 mutations, and associated with significant thrombotic and hemorrhagic complications. Women of reproductive age with MPNs face unique challenges in selecting safe and effective contraception, as these disorders inherently increase thrombotic risk and may interact with hormonal contraceptive therapies. Estrogen-containing contraceptives are contraindicated due to their association with venous and arterial thrombosis, while progestin-only and non-hormonal methods are generally safer but must be tailored to individual risks such as thrombocytopenia, prior thrombotic events, and disease-modifying therapies. This review provides a comprehensive analysis of contraceptive options for women with MPNs, exploring the thrombotic and bleeding risks associated with different methods and the potential impact of MPN treatments, including JAK2 inhibitors, on contraceptive efficacy. By synthesizing current evidence, the review aims to guide clinicians in optimizing reproductive health for women with MPNs while minimizing the risks of their underlying hematologic condition.

Indexed as

ContraceptionMyeloproliferative DisordersFemaleHumansJanus Kinase 2Janus Kinase 2contraceptionhormonesmyeloproliferative neoplasmsthrombosis

Identifiers

PMID40717686
PMCPMC12402848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.