ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The clinical Alzheimer's disease spectrum classified in the A/T/N framework withEuropean journal of nuclear medicine and molecular imaging · 2026Observational
- CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression.medRxiv : the preprint server for health sciences · 2026Article
- Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
introductionMethods for standardizing positron emission tomography (PET) indices of β-amyloid (Aβ) (Centiloid [CL]) and tau (CenTauRz, CTRz) burden facilitates direct comparisons across radiotracers and supports in vivo biologic staging per the AT(N) (Aβ [A], tau [T], and neurodegeneration [N]) framework. In lieu of post mortem examination, visual interpretation is the most sensitive indicator of these pathologies. Here, we compared the performance of analytic and visual methods of AT(N) staging.
methodsA total of 149 participants were imaged using Pittsburgh Compound B ([
resultsCL quantification showed excellent agreement with visual Aβ staging, whereas T status derived from the CTRz pipeline was less sensitive to the heterogeneity of tau pathologic presentations indicated visually. Poor concordance was observed between visual and analytic N status. DISCUSSION: A combination of visual and analytic information is optimal for accurate biologic staging of AD. HIGHLIGHTS: The Centiloid method showed strong agreement with visual assessment for β-amyloid (Aβ) status. The CenTauR method was less sensitive than visual assessment for tau status. Heterogeneous tau deposition complicates tau standardization methods. Cortical thickness might not be the optimal index of neurodegeneration.
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