Evidence map›Paper›PMID 40717619›Full record

ArticleJournal of neuroendocrinology2025

White paper on best practices for translational research in neuroendocrine neoplasms.

Jerome Cros, Oriol Casanovas, Justo P Castaño, Talya Dayton, Alejandro Garcia Alvarez, Benjamin Gibert, Michele Simbolo, Timon Vandamme, Mauro Cives, Ilaria Marinoni and 1 more

Abstract readConsensus Statement
In one paragraph

Article in Journal of neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jerome CrosDepartment of Pathology, Beaujon Hospital (AP-HP), Université Paris Cité, Paris, France.
Oriol CasanovasProCURE, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
Justo P CastañoMaimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.
Talya DaytonTissue Biology and Disease Modelling, European Molecular Biology Laboratory (EMBL) Barcelona, Barcelona, Spain.
Alejandro Garcia AlvarezGastrointestinal and Endocrine Tumor Unit, Medical Oncology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Benjamin GibertGastroenterology and Technologies for Health, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Lyon, France.
Michele SimboloSection of Pathology, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Timon VandammeIntegrated Personalized and Precision Oncology Network (IPPON), Center for Oncological Research (CORE), University of Antwerp and Antwerp University Hospital, Wilrijk, Belgium.
Mauro CivesInterdisciplinary Department of Medicine, University of Bari "Aldo Moro," Bari, Italy.ORCID https://orcid.org/0000-0002-3013-1816
Ilaria MarinoniInstitute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.
ENETS Basic and Translational Research Group (BTRG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating state-of-the-art technologies including bulk and single-cell genomics, transcriptomics, and proteomics in contemporary NEN research. We also provide insights on how to properly handle tissue samples (particularly when starting material is limited) and discuss technical hints of relevance when planning liquid biopsy or tumor immunology studies. Future translational studies of NENs will benefit from centralized biologic material biobanking, research design planning in the context of multi-expertise committees, as well as experimental protocol optimization and sharing across the NEN scientific community.

Indexed as

Neuroendocrine TumorsPractice Guidelines as TopicTranslational Research, BiomedicalHumansProteomicscarcinoidsgenomicsliquid biopsymodelstranscriptomics

Identifiers

PMID40717619
PMCPMC12488366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.