ReviewCytoskeleton (Hoboken, N.J.)2026
KIF14 as a Dual Microtubule/F-Actin Binding Protein Contributing to Cytokinesis.
Review in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- KIF14 as a Dual Microtubule/F-Actin Binding Protein Contributing to Cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cytokinesis, the final step of cell division, necessitates precise coordination between the microtubule-based central spindle and the actomyosin contractile ring. KIF14, a member of the kinesin-3 family of motor proteins, has emerged as a crucial integrator of these cytoskeletal systems. This review consolidates recent advances in understanding KIF14's structural domains, its dual-binding capacity for microtubules and F-actin, and its mechanochemical characteristics. KIF14 collaborates with protein regulator of cytokinesis 1 (PRC1) to bundle and slide antiparallel microtubules, while phosphorylation mediated by NIMA related kinase 7 (Nek7) enables KIF14 to bind and transport Citron kinase (CIT-K) to the midbody. This process connects central spindle organization to RhoA-driven contractility. In addition, KIF14 interacts with centralspindlin components and actomyosin regulators, thereby reinforcing midzone integrity and promoting cleavage furrow ingression. Its persistent midbody localization and activity regulated by phosphorylation ensure the temporal coordination of late cytokinesis events. Collectively, these functions establish KIF14 as a dual-function integrator of spindle architecture and contractile-ring constriction, making it indispensable for successful cell division.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.