ArticleThe Permanente journal2025
Optimizing Care for Neutropenic Fever in Pediatric Patients: An Analysis of Treatment Approaches and Clinical Outcomes.
Article in The Permanente journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Blinatumomab for treatment of children with acute lymphoblastic leukaemia in Hong Kong: A cost-effectiveness analysis.British journal of haematology · 2026Article
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5 authors.
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Abstract
introductionFebrile neutropenia is a serious complication in pediatric oncology. Kaiser Permanente Northern California hospitals use varying fever thresholds for admission criteria: the Kaiser Permanente Oakland hospital employs a threshold of 101.5 °F, and Kaiser Permanente Roseville and Kaiser Permanente Santa Clara use lower thresholds. This study aims to assess the potential risks associated with adopting different fever thresholds, including bacteremia, pediatric intensive care unit (PICU) transfer, septic shock, and length of hospital stay.
methodsThis retrospective cohort study includes Kaiser Permanente Northern California members aged 1 to 18 years with an oncologic diagnosis admitted to 1 of 3 Kaiser Permanente Northern California hospitals with neutropenic fever between 2016 and 2022. Patients admitted with a fever ≥ 101.5 °F (high-temperature group) were compared to those admitted with a fever < 101.5 °F (low-temperature group).
resultsThe study cohort included 177 patients with a mean age of 8.2 ± 5.4 years, 59.3% male. Of these patients, 70 (39.6%) were in the low-temperature group, and 107 (60.5%) were in the high-temperature group. Overall, 24 (13.6%) patients developed bacteremia, and 24 (13.6%) required PICU transfer. Comparisons between the low- and high-temperature groups showed no statistically significant differences in rates of bacteremia (8.6% vs 16.8%, DISCUSSION AND
conclusionFuture studies with larger sample sizes are needed to validate these findings. Similar studies evaluating outcomes based on admitting temperature can shed light on the most appropriate fever threshold for admission to optimize outcomes for pediatric oncology patients.
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