Evidence map›Paper›PMID 40717423›Full record

SynthesisAnaesthesia2025

Consensus recommendations for paediatric airway topicalisation using lidocaine.

Helen A Iliff, Julia Parnell, Paul A Baker, Alistair Baxter, Rachel Chapman, James Coulson, Catherine Dotherty, Yasmin Endlich, Peter Frykholm, Jane Harkin and 14 more

Abstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Helen A IliffDepartment of Anaesthesia, Cardiff and Vale University Health Board, Cardiff, UK.ORCID 0000-0002-3468-2199
Julia ParnellDepartment of Anaesthesia, Swansea Bay University Health Board, Swansea, UK.
Paul A BakerDepartment of Anaesthesiology, University of Auckland, New Zealand.ORCID 0000-0001-9131-8150
Alistair BaxterDepartment of Anaesthesia, Royal Hospital for Children and Young People, Edinburgh, UK.
Rachel ChapmanDepartment of Anaesthesia and Pain Management, The Royal Children's Hospital, Melbourne, Australia.
James CoulsonCardiff University, Cardiff, UK.
Catherine DothertyDepartment of Anaesthesia, Royal Manchester Children's Hospital, Manchester, UK.
Yasmin EndlichDepartment of Anaesthesia, Royal Adelaide Hospital, Adelaide, Australia.ORCID 0000-0002-8804-4168
Peter FrykholmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Jane HarkinRoyal Adelaide Hospital, Adelaide, Australia.
Narasimhan JagannathanDepartment of Anesthesia, Phoenix Children's Hospital, Phoenix, AZ, USA.
Haytham KubbaDepartment of Paediatric Otorhinolaryngology, Royal Hospital for Children, Glasgow, UK.ORCID 0000-0003-3245-5117
Jackson Kwizera NdekeziDepartment of Anesthesia and Critical Care, African Health Sciences University, Rwanda.
Barry McGuireDepartment of Anaesthesia, Ninewells Hospital, Dundee, UK.ORCID 0000-0003-4047-1571
Ahmed MesbahDepartment of Anesthesiology, The Hospital for Sick Children, Toronto, Canada.ORCID 0000-0002-6788-6059
Rania MehannaDepartment of Paediatric Otorhinolaryngology, Children's Health at Crumlin, Dublin, Ireland.ORCID 0000-0002-2569-5043
Alice MiskovicDepartment of Anaesthesia, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0003-3863-4976
Richard NewtonDepartment of Anaesthesia, University Hospitals Sussex, Brighton, UK.
Nara OrbanDepartment of Otorhinolaryngology, St Bartholomew's and The Royal London Hospitals, London, UK.
Sarah PerryChildren's Hospital for Wales, Cardiff, UK.
James PeytonDepartment of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-2667-9344
Kate RivettPatient Representative, London, UK.
Mari RobertsDepartment of Anaesthesia, Children's Hospital for Wales, Cardiff, UK.
Keno TemoDepartment of Anaesthesia, Port Moresby General Hospital, Port Moresby, Papua New Guinea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLidocaine is commonly used to provide airway topicalisation in children. However, there is a paucity of evidence and no guidance available on safe dosing practices.

methodsAn international expert multidisciplinary, multi-society working group conducted a systematic review of the literature, followed by a three-round Delphi process to produce consensus recommendations. These recommendations aim to improve the safety of children having their airways topicalised with lidocaine.

resultsThe systematic review identified 26 articles, with 21 recommendations agreed across five domains of practice: dosing; recovery; adverse reactions; institutional responsibilities; and learning from events. Evidence was limited and mainly grades C and D but the strength of the recommendations, based on the expert consensus, was mainly moderate (65-79% consensus) and strong (≥ 80% consensus). DISCUSSION: It is hoped these consensus recommendations will promote safe practice when lidocaine is used for airway topicalisation in children.

Indexed as

Airway ManagementAnesthetics, LocalLidocaineAdministration, TopicalChildDelphi TechniqueHumansAnesthetics, LocalLidocainelidocainelignocainepaediatric airwaytopicalisation

Identifiers

PMID40717423
PMCPMC12434445

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.