Evidence map›Paper›PMID 40717202›Full record

ArticlePsychopharmacology2026

ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO

Letícia R Pinheiro, Alana T Frias, Luis Gustavo A Patrone, Kênia C Bícego, Hélio Zangrossi, Luciane H Gargaglioni

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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Letícia R PinheiroDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Rod. Prof. Paulo Donato Castellane S/N, Jaboticabal, SP, 14884-900, Brazil.
Alana T FriasDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Rod. Prof. Paulo Donato Castellane S/N, Jaboticabal, SP, 14884-900, Brazil.
Luis Gustavo A PatroneDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Rod. Prof. Paulo Donato Castellane S/N, Jaboticabal, SP, 14884-900, Brazil.
Kênia C BícegoDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Rod. Prof. Paulo Donato Castellane S/N, Jaboticabal, SP, 14884-900, Brazil.
Hélio ZangrossiDepartment of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Luciane H GargaglioniDepartment of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Rod. Prof. Paulo Donato Castellane S/N, Jaboticabal, SP, 14884-900, Brazil. luciane.gargaglioni@unesp.br.ORCID http://orcid.org/0000-0003-4097-5286

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302991/2022-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/01702-2
6 · The paper itself

Abstract

rationaleThere is a connection between respiratory pathologies and panic disorder, since episodes of hypercapnia can trigger anxiety-related behaviors. The locus coeruleus (LC) is a CO

objectivesOur study investigated the role of ASIC1a channels in the LC in detecting hypercapnic acidosis and their participation in the respiratory and behavioral responses induced by CO

methodsWe tested the effects of injection of an ASIC1a antagonist [Psalmotoxin-1 (Pstx-1-50 ng/0.1uL)] into the LC of C57BL/6 male and female mice on respiratory, metabolic, and behavioral responses to 20% CO

resultsPstx-1 intra-LC did not change ventilation and metabolism under normocapnic and hypercapnic conditions in both male and female mice. As to CO

conclusionsASIC1a channels in the LC do not participate in respiratory control under normocapnia and hypercapnia, but are involved in CO

Indexed as

AcidosisAcid Sensing Ion ChannelsCarbon DioxideHypercapniaLocus CoeruleusPanicAcid Sensing Ion Channel BlockersAnimalsBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLNeuronsPanic DisorderPatch-Clamp TechniquesAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsASIC1 protein, mouseCarbon DioxidePcTX1 protein, Psalmopoeus cambridgeiPeptidesSpider VenomsAcidAnxietyChemosensitivityHypercapniaPanic disorderVentilation

Identifiers

PMID40717202

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.