Evidence map›Paper›PMID 40717094›Full record

ArticleVirology journal2025

Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism.

Meng Yu, Xianjuan Zhang, Zhifei Wang, Shan Wang, Jun Li, Huan Huang, Xu Li, Chen Wang, Wen Shen, Weiwei Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meng Yu *Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Xianjuan Zhang *Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
Zhifei WangDepartment of Clinical Laboratory, Affiliated Women and Children's Hospital of Qingdao University, Qingdao, Shandong province, China.
Shan WangDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Jun LiDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Huan HuangDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Xu LiDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Chen WangDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Wen ShenDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.
Weiwei SunSchool of Health Management, Hengxing University, Qingdao, Shandong Province, China.
Jie YuSchool of Health Management, Hengxing University, Qingdao, Shandong Province, China.
Wanming ZhangQingdao Wanming Biopharmaceutical Co., Ltd., Qingdao, Shandong Province, China.
Yunyang WangDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China. wangyy_09@outlook.com.
Bin WangDepartment of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China. wangbin532@126.com.

Funding

National Key Research and Development Program of China 2018YFA0900802Qingdao Municipal Science and technology Foundation 20-23-4-nshShandong Provincial Science and technology Foundation 2019JZZY011009
6 · The paper itself

Abstract

Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurodevelopmental disorders in children, including nongenetic sensorineural hearing loss. Previous studies have shown that HCMV immediate early 1 (IE1) protein, also known as IE72, contributes to brain maldevelopment. However, the underlying mechanisms are unclear due to the strict species specificity of cytomegaloviruses (CMVs), limiting animal model study. In the current study, we used CRISPR/Cas9 technology to construct a transgenic mouse model (Rosa26-LSL-IE1

Indexed as

AstrocytesBrainCytomegalovirusCytomegalovirus InfectionsImmediate-Early ProteinsNeuroinflammatory DiseasesAnimalsDisease Models, AnimalHumansMiceMice, TransgenicMicrogliaNeurodevelopmental DisordersNeuronsIE1 protein, cytomegalovirusImmediate-Early ProteinsHuman cytomegalovirus (HCMV)Immediate early 1 (IE1) proteinMetabolic reprogrammingNeuroinflammationTransgenic mouse model

Identifiers

PMID40717094
PMCPMC12302570

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.