Observational studyCritical care (London, England)2025
Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in patients with ARDS: a prospective observational study.
Observational study in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in intubated patients with moderate-to-severe ARDS: a prospective physiological study.Respiratory research · 2026Trial
- Ventilation/perfusion mismatch measured by electrical impedance tomography at the bedside: potentialities and challenges.Intensive care medicine · 2026Review
- Optimizing aerosol therapy in mechanically ventilated acute respiratory distress syndrome: a delivery-fidelity framework.Frontiers in medicine · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur study aimed to assess the effects of inhaled nitric oxide (iNO) on ventilation/perfusion mismatch, and individual variability in patients with acute respiratory distress syndrome (ARDS) by electrical impedance tomography (EIT).
methodsThis single-center, prospective physiological study enrolled mechanically ventilated ARDS patients. All patients initially received 5 ppm iNO; responders (≥ 20% increase in PaO
resultsAt 30 min, 36.7% (11/30) of patients responded, associated with younger age and lower prevalence of hypertension. Among responders, the proportion of ventral perfusion significantly increased at 3 h, with this change already observed at 30 min. Responders also showed a significant reduction in the proportion of only perfused units in the dorsal region at 30 min; at the whole-lung level, the proportions of only perfused units and unmatched units decreased. In contrast, non-responders showed an increased proportion of only perfused units in both the dorsal region and whole lung at 3 h compared to baseline, following prolonged high-dose iNO administration.
conclusionsThe response to iNO varied. In responders, EIT showed a potential redistribution of lung perfusion toward ventral regions, with reductions in the proportions of only perfused units and unmatched units in the whole lung.
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Registered trials
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