Evidence map›Paper›PMID 40716670›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025

Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder.

Lachlan Webb, Luke J Hearne, Ye E Tian, Andrew Zalesky, Conor Robinson, Caitlin V Hall, Saurabh Sonkusare, Bjorn Burgher, Michael Breakspear, Garance M Meyer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lachlan WebbClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: lachlan.webb@qimrberghofer.edu.au.
Luke J HearneClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, University of Queensland, Brisbane, Queensland, Australia.
Ye E TianDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.
Andrew ZaleskyDepartment of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria, Australia.
Conor RobinsonClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, University of Queensland, Brisbane, Queensland, Australia.
Caitlin V HallClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Saurabh SonkusareClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; College of Engineering Science and Environment, College of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
Bjorn BurgherClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Michael BreakspearClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; College of Engineering Science and Environment, College of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
Garance M MeyerCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Andreas HornCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Institute for Network Stimulation, Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.
Sebastien NazeClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Philip MosleyClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Australian eHealth Research Centre, The Commonwealth Scientific and Industrial Research Organization Health and Biosecurity, Herston, Queensland, Australia.
Luca CocchiClinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, University of Queensland, Brisbane, Queensland, Australia. Electronic address: lucacocchineuro@gmail.com.

Funding

Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892
6 · The paper itself

Abstract

backgroundObsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organization of striatal connections.

methodsWe calculated spatial striatal gradients linked to whole-brain activity in 52 people with OCD and 45 control participants. Gradients were computed with individuals at rest and when they underwent a threat-safety reversal task. Using a longitudinal dataset of 47 people with OCD, we investigated possible associations between changes in striatal gradient topology and fluctuations in symptom severity.

resultsResults showed group differences in the main gradient topology at rest, specifically in striatal regions that overlap with the putamen and caudate. Individuals who showed a reduction in symptoms over time tended to change their gradient topology in favor of the control participants' average topology. Finally, gradients linked to the appraisal of safety reversal, but not threat reversal, showed a group difference in a region separating the right nucleus accumbens and the putamen.

conclusionsThis study advances knowledge of striatal connectivity profiles in OCD, supporting a core role of distinct changes in striatal topology in the expression of symptoms. Collectively, these results encourage studies assessing neural mechanisms that drive the dynamic reorganization of striatal topology and the development of therapies that leverage striatocortical plasticity.

Indexed as

Corpus StriatumObsessive-Compulsive DisorderAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPutamenYoung AdultCompulsivityfMRIGradientsLongitudinal changesObsessive-compulsive disorder

Identifiers

PMID40716670
PMCPMC13095160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.