Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Gabriella M SilvaDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Amber L KaplanDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Celeste R ParkDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Joseph A PiconeDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
R Kijoon KimDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Natalie L TrubyDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Rachel L NeveGene Delivery Technology Core, Massachusetts General Hospital, Cambridge, Massachusetts.
Xiaohong CuiDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Peter J HamiltonDepartment of Neuroscience and Anatomy, Virginia Commonwealth University School of Medicine, Richmond, Virginia. Electronic address: peter.hamilton@vcuhealth.org.
Funding
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
Cell type transcriptional mechanisms of polysubstance choiceR01DA058958 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew L Banks, Peter James Hamilton · 2023 to 2026
$1.8M
Reprogramming KZFP function to understand drug-specific transcription and behaviorR01DA058089 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Peter James Hamilton · 2024 to 2026
$1.5M
Using CRISPR tools to uncover the role of CREB-gene regulation in drug abuseR00DA045795 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAMILTON, PETER JAMES · 2020 to 2022
$739k
Neurocognitive, genetic and socioenvironmental influences on a developmental precursors to addiction: A cross-species studyR34DA061267 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BANKS, MATTHEW L, BOUNTRESS, KAITLIN ELIZABETH · 2024 to 2025
$689k
VCU Initiative for Maximizing Student Development Program (IMSD)T32GM148403 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, ESCALANTE, CARLOS R · 2023 to 2025
backgroundEarlier work has established that Zfp189, which encodes a KZFP transcription factor (TF), differentially accumulates in nucleus accumbens (NAc) Drd1+ and Drd2+ medium spiny neurons (MSNs) and drives MSN functional and behavioral adaptations to cocaine. Here, we aimed to illuminate the cell type mechanisms through which this TF contributes to cocaine adaptations, with emphasis on investigating transposable elements (TEs).
methodsFirst, we annotated TEs in existing single-nucleus RNA sequencing (snRNAseq) from rodents exposed to either acute or repeated cocaine. To directly test whether TE dysregulation participates in cocaine-related brain changes, we virally delivered synthetic ZFP189 TFs, capable of releasing (ZFP189
resultsWe discovered that NAc TE transcript expression was dramatically increased by cocaine experience, and the most sensitive NAc cell types were Drd1+, followed by Drd2+ MSNs. Our snRNAseq revealed that ZFP189
conclusionsThis research points to TE transcript expression as dynamically regulated within NAc MSNs and possibly involved in producing the molecular and behavioral responses to cocaine.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Transposable Elements Are Dynamically Regulated in Medium Spiny Neurons and May Contribute to the Molecular and Behavioral Adaptations to Cocaine. · full record | OpenQuestion