Evidence map›Paper›PMID 40716444›Full record

SynthesisThe Lancet. Microbe2025

Identifying genomic surveillance gaps in Africa for the global public health response to West Nile virus: a systematic review.

Monika Moir, Nikita Sitharam, Laura Marije Hofstra, Graeme Dor, Gaspary Mwanyika, Yajna Ramphal, Martina L Reichmuth, James Emmanuel San, Robert Gifford, Eduan Wilkinson and 18 more

Abstract readSystematic Review
In one paragraph

Synthesis in The Lancet. Microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Monika MoirCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa. Electronic address: monikam@sun.ac.za.
Nikita SitharamCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Laura Marije HofstraCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Graeme DorCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Gaspary MwanyikaCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa; Department of Applied Sciences, Mbeya University of Science and Technology, Mbeya, Tanzania.
Yajna RamphalCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Martina L ReichmuthInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
James Emmanuel SanDuke Human Vaccine Institute, Duke University, Durham, NC, USA; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Robert GiffordCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Eduan WilkinsonCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Derek TshiabuilaCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Wolfgang PreiserDivision of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Matieland, South Africa; National Health Laboratory Service, Tygerberg Campus, Cape Town, South Africa.
Abla Ahouefa KonouLaboratoire de Biologie moléculaire et d'Immunologie (BIOLIM/FSS-UL), Université de Lomé, Lomé, Togo.
Molalegne BitewBio and Emerging Technology Institute, Addis Ababa, Ethiopia.
Anyebe Bernard OnojaDepartment of Virology, University of Ibadan, Ibadan, Nigeria.
Giacomo Maria PaganottiBotswana-University of Pennsylvania Partnership, Gaborone, Botswana; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adugna AberaEthiopian Public Health Institute, Addis Ababa, Ethiopia.
James Ayei MarorNational Public Health Laboratory, Ministry of Health, Juba, South Sudan.
John KayiwaUganda Virus Research Institute, Entebbe, Uganda.
Sara AbuelmaaliNational Public Health Laboratory, Khartoum, Sudan.
Eddy Kinganda LusamakiInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo; Service de Microbiologie, Département de Biologie Médicale, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo; TransVIHMI, Université de Montpellier, INSERM, IRD, Montpellier, France.
CLIMADE Consortium
Marietjie VenterEmerging Viral Threat, One Health Surveillance and Vaccines Division, Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa; Centre for Emerging Arbo and Respiratory Virus Research, Department Medical Virology, Faculty of Health, University of Pretoria, Pretoria, South Africa.
Felicity BurtDivision of Virology, National Health Laboratory Services, Universitas Hospital, Bloemfontein, South Africa; Pathogen Research Laboratory, Division of Virology, University of the Free State, Bloemfontein, South Africa.
Cheryl BaxterCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.
Richard LessellsKwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.
Tulio de OliveiraCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.
Houriiyah TegallyCentre for Epidemic Response and Innovation, School for Data Science and Computational Thinking, Stellenbosch University, Matieland, South Africa.

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
NIAID NIH HHS U01 AI151698Wellcome Trust
6 · The paper itself

Abstract

West Nile virus (WNV) is a priority pathogen that poses a high risk for public health emergencies of global concern. Although WNV is endemic to Africa, only few (n=63) whole genomic sequences are available from the continent. In this Review, we examined the status of the molecular testing and genomic sequencing of WNV across Africa and mapped its global spatiotemporal spread. WNV has been detected in 39 African countries, the Canary Islands, and Réunion Island. Although publications, including those with molecular data, originated from 24 of these countries, genomic sequences were available from only 16 countries. Our analysis identified regions with detected viral circulation but without molecular surveillance. The current literature has substantial knowledge gaps in terms of the disease burden, molecular epidemiology, and distribution of WNV in Africa. Addressing these gaps requires an integrated One Health surveillance approach, which is challenging to establish. We propose three key surveillance needs that could improve the current understanding of the WNV disease burden in Africa, to strengthen the global public health response to this vector-borne disease.

Indexed as

Public HealthWest Nile FeverWest Nile virusAfricaAnimalsGenome, ViralGenomicsGlobal HealthHumansMolecular Epidemiology

Identifiers

PMID40716444
PMCPMC12769835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.