ReviewSeminars in cell & developmental biology2025
C. elegans: An elegant experimental system for the study of cilia biology.
Review in Seminars in cell & developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Functions and trafficking mechanisms of RIC-8 inMolecular biology of the cell · 2026Article
- The extracellular matrix genebioRxiv : the preprint server for biology · 2026Article
- Cell-specific roles for the conserved Galpha chaperone RIC-8 in cilia biology.bioRxiv : the preprint server for biology · 2026Article
- Complement Factor H and itsbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Caenorhabditis elegans is a genetically tractable organism that has become one of the leading in vivo models for cilia research. Cilia are not required for viability in C. elegans, as only a subset of sensory neurons is ciliated in this organism. Yet, C. elegans cilia exhibit remarkable structural and functional diversity akin to their mammalian counterparts. Since the core mechanisms of cilia assembly are evolutionarily conserved, research in C. elegans has informed studies in other organisms on cilia biogenesis, trafficking, and functions and has provided key insights into mechanisms of cilia dysfunction in human disorders. Here, we provide a general overview of the C. elegans model for cilia research. Specifically, we review different cilia types and their underlying ultrastructural organization, discuss trafficking mechanisms for ciliary proteins, describe emerging functions of ciliary extracellular vesicles, and highlight a broad swathe of sophisticated tools available in C. elegans for studying multiple aspects of cilia biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.