Evidence map›Paper›PMID 40716030›Full record

ArticleThe New phytologist2025

The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.

Maria Mineiro, Raphaël Groux, Caroline Gouhier-Darimont, Pierre Mateo, Christelle Aurélie Maud Robert, Philippe Reymond

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Mineiro *Department of Plant Molecular Biology, University of Lausanne, Lausanne, 1015, Switzerland.ORCID https://orcid.org/0009-0002-7117-6380
Raphaël Groux *Department of Plant Molecular Biology, University of Lausanne, Lausanne, 1015, Switzerland.ORCID https://orcid.org/0000-0002-5668-5067
Caroline Gouhier-DarimontDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, 1015, Switzerland.
Pierre MateoInstitute of Plant Sciences, University of Bern, Bern, 3013, Switzerland.ORCID https://orcid.org/0000-0003-4338-3024
Christelle Aurélie Maud RobertInstitute of Plant Sciences, University of Bern, Bern, 3013, Switzerland.ORCID https://orcid.org/0000-0003-3415-2371
Philippe ReymondDepartment of Plant Molecular Biology, University of Lausanne, Lausanne, 1015, Switzerland.ORCID https://orcid.org/0000-0002-3341-6200

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_200372
6 · The paper itself

Abstract

Upon perception of insect eggs, Arabidopsis thaliana activates a generic immune response that culminates in cell death (hypersensitive-like response (HR-like)). While this response can subsequently impact egg survival, the molecular mechanisms are poorly understood. Through a genome-wide association study (GWAS), we identified the amino acid-gated calcium channel GLUTAMATE-LIKE RECEPTOR2.7 (GLR2.7) as an important gene controlling the extent of HR-like and accumulation of salicylic acid (SA) in response to egg extract of Pieris brassicae. Analysis of natural polymorphisms showed that two major haplotypes segregate at the species-wide level and suggests that balancing selection acts at this locus. Insect oviposition triggered a long-lasting localized cytosolic calcium accumulation that depended on GLR2.7 and was linked with egg-associated glutamate (Glu). We propose that Glu-activated GLR2.7 is involved in egg perception and early immune responses.

Indexed as

ArabidopsisArabidopsis ProteinsButterfliesOvumReceptors, GlutamateAnimalsCalciumGene Expression Regulation, PlantGenome-Wide Association StudyGlutamic AcidHaplotypesOvipositionSalicylic AcidArabidopsis ProteinsCalciumGlutamic AcidReceptors, GlutamateSalicylic AcidArabidopsiscalcium influxgenome‐wide association studyGLR2.7glutamatehypersensitive‐like responseinsect eggsPieris brassicaesalicylic acid

Identifiers

PMID40716030
PMCPMC12445815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.