Evidence map›Paper›PMID 40716019›Full record

ArticleBiomolecular NMR assignments2025

Backbone assignment of a 28.5 kDa class A extended spectrum β-lactamase by high-field, carbon-detected solid-state NMR.

Christopher G Williams, Songlin Wang, Alexander F Thome, Owen A Warmuth, Varun Sakhrani, Leighton Coates, Chad M Rienstra, Leonard J Mueller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. NMR crystallography reveals active-site protonation states of Toho-1 β-lactamase in complex with avibactam.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Christopher G WilliamsDepartment of Chemistry, University of California, Riverside, CA, 92521, USA.ORCID http://orcid.org/0009-0009-8319-4413
Songlin WangDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0002-7588-7377
Alexander F ThomeDepartment of Chemistry, University of California, Riverside, CA, 92521, USA.
Owen A WarmuthDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Varun SakhraniDepartment of Chemistry, University of California, Riverside, CA, 92521, USA.
Leighton CoatesOak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA.ORCID http://orcid.org/0000-0003-2342-049X
Chad M RienstraDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0002-9912-5596
Leonard J MuellerDepartment of Chemistry, University of California, Riverside, CA, 92521, USA. leonard.mueller@ucr.edu.ORCID http://orcid.org/0000-0002-2607-9875

Funding

Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Structural and proton dynamics of pyridoxal-5’-phosphate dependent enzymes Resubmission (Equipment Supplement)R01GM137008 · NIGMS · UNIVERSITY OF GEORGIA · PI KOVALEVSKYI, ANDRII Y, MUELLER, LEONARD J · 2020 to 2023
$2.8M
NMR crystallography: Imaging active site chemistry and protonation statesR35GM145369 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Leonard J Mueller · 2022 to 2026
$2.1M
National Science Foundation, United States 1946970NIGMS NIH HHS P41 GM136463NIGMS NIH HHS R01 GM137008NIGMS NIH HHS R24 GM141526NIGMS NIH HHS R35 GM145369NIH HHS P41GM136463NIH HHS R01GM137008
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta-LactamasesCarbonNuclear Magnetic Resonance, BiomolecularMolecular Weightbeta-LactamasesCarbon1.1 GHz NMRBackbone chemical shift assignmentsProtein solid-state NMRToho-1 β-lactamase

Identifiers

PMID40716019
PMCPMC12981688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.