Evidence map›Paper›PMID 40715901›Full record

ArticleJournal of cancer research and clinical oncology2025

The risk of mortality from multiple primary cancers in colorectal cancer survivors: analysis of data from the South Australian Cancer Registry.

Mulugeta Melku, Oliver G Best, Jean M Winter, Lauren A Thurgood, Ganessan Kichenadasse, Molla M Wassie, Muktar Ahmed, Erin L Symonds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mulugeta MelkuFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia. gobe0011@flinders.edu.au.ORCID http://orcid.org/0000-0002-3383-9377
Oliver G BestFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0003-2685-3880
Jean M WinterFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0002-2041-8602
Lauren A ThurgoodFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0002-6183-2797
Ganessan KichenadasseFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0001-9923-5149
Molla M WassieFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0002-3565-2397
Muktar AhmedFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0002-9524-7027
Erin L SymondsFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.ORCID http://orcid.org/0000-0003-2451-0358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColorectal cancer (CRC) survivors face an increased risk of multiple primary cancers (MPCs), but evidence on MPC-related mortality is limited.

methodsUsing data from the South Australian Cancer Registry (1982-2017), this retrospective study analysed CRC survivors diagnosed with MPCs, defined as distinct primary cancers arising ≥ 2 months after CRC diagnosis. Causes of death were categorised as index CRC, MPC, or non-cancer related. Poisson regression estimated cancer-specific mortality risk compared to the general population. Propensity score weighting was applied to balance covariate distribution between CRC survivors with and without MPC groups. A hazard ratio (HR) for all-cause mortality was estimated using a weighted dataset to assess the impact of MPC on overall survival.

resultsAmong 26,093 CRC survivors (181,877 person-years follow-up), the age-standardised MPC-related mortality rate was 240 per 100,000 population. Gastrointestinal, lung, haematological, and urinary tract cancers were the most common MPC-related causes of death. CRC survivors had a 45% higher risk of dying from MPCs than the general population (standardised mortality ratio = 1.45, 95%CI 1.38-1.52). Adjusted analyses showed a 58% increase in all-cause mortality among CRC survivors with MPCs (HR = 1.58, 95%CI 1.51-1.65).

conclusionsCRC survivors with MPC face significantly worse survival compared to those with a single primary CRC. Early detection and management of MPCs are essential for improving long-term survival in individuals diagnosed with CRC.

Indexed as

Cancer SurvivorsColorectal NeoplasmsNeoplasms, Multiple PrimaryAdultAgedAged, 80 and overCause of DeathFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesRisk FactorsSouth AustraliaSurvival RateColorectal cancerHazard ratioMortalityMultiple primary cancerStandardised mortality ratio

Identifiers

PMID40715901
PMCPMC12297194

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.