Evidence map›Paper›PMID 40715888›Full record

ArticleDiscover oncology2025

Notch1 and CyclinD1 expression and significance in jaw ameloblastoma: an immunohistochemical analysis.

Baoyinbatu Gabiyatu, Wenchao Li, Rihan Wu, Yuan Tian, Senhao Li, Sarnai Tsagaankhuu, Li-Dao Bao, Damdindorj Boldbaatar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Baoyinbatu Gabiyatu *Department of Health Research, Graduate School of Mongolian National, University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
Wenchao Li *Department of Oral Implantology, Inner Mongolia Key Laboratory of Oral Craniomaxillofacial Diseases Research, Affiliated Hospital of Chifeng University, Chifeng, 024000, Inner Mongolia, China.
Rihan WuDepartment of Surgery, Affiliated Hospital of Chifeng University, Chi Feng, 024000, Inner Mongolia, China.
Yuan TianDepartment of Oral Implantology, Inner Mongolia Key Laboratory of Oral Craniomaxillofacial Diseases Research, Affiliated Hospital of Chifeng University, Chifeng, 024000, Inner Mongolia, China.
Senhao LiDepartment of Oral Implantology, Inner Mongolia Key Laboratory of Oral Craniomaxillofacial Diseases Research, Affiliated Hospital of Chifeng University, Chifeng, 024000, Inner Mongolia, China.
Sarnai TsagaankhuuDepartment of Health Research, Graduate School of Mongolian National, University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
Li-Dao BaoDepartment of Oral Implantology, Inner Mongolia Key Laboratory of Oral Craniomaxillofacial Diseases Research, Affiliated Hospital of Chifeng University, Chifeng, 024000, Inner Mongolia, China.
Damdindorj BoldbaatarDepartment of Physiology, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia. 25891814@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAmeloblastoma (AM), a frequently encountered odontogenic epithelial neoplasm, demonstrates complex molecular pathogenesis involving dysregulation of cellular signaling networks. This study investigated the clinicopathological significance of Notch1 signaling pathway activation and its downstream effector CyclinD1 in jaw ameloblastoma progression.

methodsImmunohistochemical profiling was conducted on 66 archived AM specimens and 23 normal oral mucosa (NOM) controls. Protein localization patterns and expression intensities were systematically analyzed using chi-square tests, Fisher's exact test, and Spearman's rank correlation (significance threshold α = 0.05).

resultsA notable proportion of jaw AM samples exhibited marked immunoreactivity for Notch1 and CyclinD1 proteins, predominantly localized in the cellular membrane and cytoplasm. Significantly elevated levels of Notch1 and CyclinD1 proteins were evident in AM compared to NOM (P < 0.05). The protein expression levels showed no association with AM subtype (P > 0.05), while a positive correlation between Notch1 and CyclinD1 expression was noted in AM (r = 0.509, P < 0.05).

conclusionsThe coordinated overexpression of Notch1-CyclinD1 axis in ameloblastoma pathogenesis suggests their synergistic involvement in tumor proliferation dynamics. These findings position the Notch signaling pathway as a potential therapeutic target for AM management strategies.

Indexed as

AmeloblastomaCyclinD1Notch1Proliferation

Identifiers

PMID40715888
PMCPMC12297205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.