Evidence map›Paper›PMID 40715818›Full record

ArticleNature medicine2025

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

De-Hua Chui, Hiroshi Tanahashi, Kazuharu Ozawa, Sachiya Ikeda, Frédéric Checler, Otoya Ueda, Hiroshi Suzuki, Wataru Araki, Haruhisa Inoue, Keiro Shirotani and 3 more

Abstract readExpression of Concern
PubMed Publisher
In one paragraph

Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

De-Hua ChuiDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Hiroshi TanahashiDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Kazuharu OzawaFuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
Sachiya IkedaFuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
Frédéric CheclerInstitut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, 06560, France.
Otoya UedaFuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
Hiroshi SuzukiFuji Gotemba Research Labs, Chugai Pharmaceutical, 1-135 Komakado, Gotemba, Shizuoka, 412-8531, Japan.
Wataru ArakiDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Haruhisa InoueDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Keiro ShirotaniDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Keikichi TakahashiDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
Ferenc GallyasDepartment of Neurosurgery, University Medical School of Pécs, Pécs, Hungary.
Takeshi TabiraDepartment of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. tabira@ncnaxp.ncnp.go.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40715818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.