Evidence map›Paper›PMID 40715805›Full record

ArticleJournal of neurology2025

Lung function and the risk of Parkinson's disease: a population-based cohort study.

Jiyong Liu, Shichan Wang, Xiaoting Zheng, Sirui Zhang, Qirui Jiang, Chunyu Li, Huifang Shang

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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiyong LiuDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Shichan WangDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Xiaoting ZhengDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Sirui ZhangDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Qirui JiangDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Chunyu LiDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Huifang ShangDepartment of Neurology, National Clinical Research Center for Geriatric, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China. hfshang2002@126.com.ORCID http://orcid.org/0000-0003-0947-1151

Funding

Sichuan Province Science and Technology Support Program 2022ZDZX0023
6 · The paper itself

Abstract

objectiveSome researchers have noted a faster decline in lung function among Parkinson's disease (PD) patients compared to healthy individuals. However, the relationship between lung function and the risk of developing PD remains unknown. This study aims to explore the association between lung function and the risk to develop PD.

methodBased on the UK Biobank, Cox proportional hazards models were used to investigate the relationship between lung function measurements, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF), and FEV1/FVC, and the risk of PD. Furthermore, this study constructed a lung function score and explore the relationship between the lung function score and PD risk. This study also conducted mediation analysis using blood inflammatory markers and metabolic indicators as mediators.

resultThis study included a total of 322,731 participants. We identified a correlation between lower lung function measures, particularly PEF and the lung function score we generated, and an increased risk of PD. Our mediation analysis highlighted several inflammatory markers, such as eosinophil, lymphocyte, monocyte, neutrophil, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammatory index, and reticulocyte, as mediators in the relationship between PEF and PD.

conclusionDeclining lung function, especially PEF and the lung function score we generated, could serve as a potential indicator for predicting the risk of PD. Inflammatory changes play a crucial role in the association, highlighting the significance of inflammatory alterations in the pathophysiology of PD.

Indexed as

LungParkinson DiseaseAgedCohort StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedRespiratory Function TestsRisk FactorsVital CapacityLung functionParkinson’s diseaseRisk factors

Identifiers

PMID40715805

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.