ReviewReproductive sciences (Thousand Oaks, Calif.)2025
Utilization of MSC-Derived Extracellular Vesicles and Bioscaffolds in Enhancing Oocyte In Vitro Maturation and Culture: A Review.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From biomolecules to breakthroughs: exosomes as next-generation theranostics in female infertility.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Failure in germ cells development and oocyte maturation remains a significant challenge in assisted reproductive technologies (ART) and can lead to feltilization failure and poor embryo quality. Rescue in vitro maturation (R-IVM) offers a promising approach to improve the reproductive outcomes in such cases. Mesenchymal stem cells-derived exosomes, have demonstrated therapeutic potential for both oocytes and granulosa cells. However, their effects on immature oocytes under R-IVM remain largely unexplored. Furthermore, incorporating exosomes into bioscaffolds may provide controlled release system, enhancing stability within IVM and in vitro culture (IVC) environments. This review evaluates the current evidence regarding the effects of MSC-derived exosomes on oocyte and granulosa cell function and explores the potential of exosome-loaded scaffolds to optimize IVM outcomes, offering new strategies for enhanced reproductive success. Recent findings indicate that bioscaffolds composed of appropriate polymers with high exosome encapsulation efficiency and a release window of 24-48 h can mimic the in vivo environment and support the maturation of oocytes and embryos in IVM/IVC systems.
Indexed as
Identifiers
40715792What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.