Evidence map›Paper›PMID 40715790›Full record

ArticleApplied microbiology and biotechnology2025

Identifying promoters to enhance heterologous gene expression in recombinant Saccharomyces cerevisiae strains cultivated on non-native substrates.

Jordan Fortuin, Riaan den Haan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jordan FortuinInstitute for Microbial Biotechnology and Metagenomics, Department of Biotechnology, University of the Western Cape, Bellville, South Africa.ORCID http://orcid.org/0000-0001-7528-806X
Riaan den HaanInstitute for Microbial Biotechnology and Metagenomics, Department of Biotechnology, University of the Western Cape, Bellville, South Africa. rdenhaan@uwc.ac.za.ORCID http://orcid.org/0000-0001-6983-6226

Funding

National Research Foundation 137967
6 · The paper itself

Abstract

Efficient bioconversion of lignocellulosic biomass (LCB) to ethanol by Saccharomyces cerevisiae requires its engineering to express heterologous enzymes at titres high enough to make significant impacts on industrial consolidated bioprocessing (CBP). Promoters are required for this purpose, but are reportedly influenced by various environmental factors as well as the protein specific nature of expression, warranting the need for assessment under the conditions for which they are intended. Heterologous xylosidase- and xylanase-encoding genes (xln43_SED1 and xyn2) were individually cloned under transcriptional control of the SED1

Indexed as

Gene ExpressionPromoter Regions, GeneticSaccharomyces cerevisiaeEndo-1,4-beta XylanasesEthanolFermentationGlucoseLigninMetabolic EngineeringRecombinant ProteinsSaccharomyces cerevisiae ProteinsXylansXyloseXylosidasesEndo-1,4-beta XylanasesEthanolGlucoseLigninlignocelluloseRecombinant ProteinsSaccharomyces cerevisiae ProteinsXylansXyloseXylosidasesConsolidated bioprocessingHeterologous expressionLignocellulosic biomassPromoterSaccharomyces cerevisiaeXylan

Identifiers

PMID40715790
PMCPMC12296805

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.