ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Irritable bowel syndrome and suicide risk among adolescents: a prospective cohort study.The Lancet regional health. Western Pacific · 2026Article
- Anterior insula reactivity to loss moderates the association between trait impulsivity and future suicidal ideation in adolescents.Developmental cognitive neuroscience · 2026Article
- Identifying Undiagnosed High-Risk Suicidality Cases by Matching Patients With a Similar Comorbidity Burden: Retrospective Observational Study.JMIR formative research · 2026Observational
- Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- The puzzle of heterogeneity: an introduction to part II.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Trajectories of mental health and mental illness: where we are now and where we go next.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Associations between COVID-19 pandemic experiences and suicidal ideation among adolescents: the mediating role of life satisfaction, subjective wellbeing, and anxiety.Frontiers in public health · 2026Article
- Examining Causal Pathways to Suicidal Ideation and Nonsuicidal Self-Injury in the Adolescent Brain Cognitive Development Study.Suicide & life-threatening behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Suicide is a leading cause of death in adolescents, and a spectrum of suicidal thoughts and behaviors (STBs) is common among teenagers. Adolescence is a transitional period marked by critical brain changes, coinciding with major changes in how teenagers regulate emotions and impulses, as well as in how they understand themselves and interact with others. We review neuroimaging evidence supporting a developmental conceptualization of suicide risk, focusing on neural changes associated with key developmental tasks of adolescence. Functional and structural imaging studies have implicated medial prefrontal, cingulate, dorsolateral prefrontal, orbitofrontal, and frontolimbic circuitry changes in youth with STBs. There is emerging evidence that psychotherapeutic and neuromodulatory interventions can engage these brain processes and modify behavior in at-risk youth. We argue that harnessing these techniques more specifically by using targeted approaches aimed at enhancing emotion regulation, impulse control, positive identity development, and healthy social functioning is a promising way forward for reducing suicide risk in teens. Continued investigation into neural trajectories of suicidality in adolescence is critical for developing more effective risk assessment and treatment approaches to aid suicidal youth in navigating adolescent development and transitioning successfully to adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.