Evidence map›Paper›PMID 40715756›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Quantitative computed tomography provides improved accuracy for diagnosis of lumbar osteoporosis in patients with facet joint osteoarthritis: a cross-sectional study.

Xiayan Wang, Chenqing Ji, Shihuai Li, Kexin Wang, Meng He, Zehao Yu, Yuanzhi Weng, Weibo Jiang, Xiongfeng Tang, Deming Guo and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Letter to the Editor: Quantitative computed tomography provides improved accuracy for diagnosis of lumbar osteoporosis in patients with facet joint osteoarthritis: a cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiayan Wang *Orthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Chenqing Ji *Orthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Shihuai LiOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Kexin WangOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Meng HeOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Zehao YuOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Yuanzhi WengOrthopaedic and Traumatology, The University of Hong Kong, Hong Kong, People's Republic of China.
Weibo JiangOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.
Xiongfeng TangOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China. tangxf921@gmail.com.
Deming GuoOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China. guodm91@jlu.edu.cn.
Yanguo QinOrthopaedic Medical Center, The Second Norman Bethune Hospital of JiLin University, Nanguan District, 218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China. qinyg@jlu.edu.cn.ORCID http://orcid.org/0000-0003-3296-3779

Funding

The 2025 Science and Technology Project of Jilin Provincial Department of Education JJKH20250174KJThe National Natural Science Foundation of China U21A20390The Special Foundation for Science and Technology Innovation of Jilin 20230204075YYThe Special Foundation for Science and Technology Innovation of Jilin YDZJ202501ZYTS090
6 · The paper itself

Abstract

This study employed both QCT and DXA to assess BMD in the same cohort and investigated the influence of FJOA on BMD measurements and the detection rates of osteoporosis. The results indicate that QCT is more accurate for assessing regional BMD in patients with FJOA. PURPOSE: This study aimed to compare the detection rates of lumbar osteoporosis in patients with FJOA between QCT and DXA and to analyze the impact of FJOA on regional BMD measurement using each method.

methodsThis single-center, retrospective, cross-sectional study included participants without a history of spinal instrumentation surgery, spinal fractures of > 2 levels, spinal tumors or infections, and sacralization of lumbar spine. The detection rates of lumbar osteoporosis between QCT and DXA in patients with FJOA were compared using McNemar's test. Associations between BMDs and FJOA severity were assessed using linear mixed models. Discordance in BMD classification between DXA and QCT was categorized as minor or major according to Woodson's definition.

resultsThe 219 study participants had a mean age of 65.0 ± 10.7 years and included 155 (70.8%) women. The rate of lumbar osteoporosis identification with QCT was noticeably greater than that with DXA (58% vs 34.2%, p < 0.0001). Severe FJOA was independently associated with lower vBMD (multivariable β =  - 4.23 (95% confidence interval (CI), - 7.68 to - 0.77); p = 0.17), while both slight-to-moderate and severe FJOA were independently associated with higher areal BMD (aBMD). With increasing FJOA severity, the aBMD measured by DXA also increased (slight-to-moderate, β = 0.31 (95% CI, 0.16-0.46), p < 0.001; severe FJOA, β = 1.03 (95% CI, 0.79-1.27), p < 0.001).

conclusionsMore severe FJOA was associated with higher aBMD on DXA and a lower vBMD on QCT. Additionally, the rate of lumbar osteoporosis detection was significantly higher with QCT than with DXA. These findings indicate that QCT is more accurate for assessing regional BMD in patients with FJOA, supporting the need for caution when using DXA to evaluate BMD in clinical practice.

Indexed as

Lumbar VertebraeOsteoarthritisOsteoporosisZygapophyseal JointAbsorptiometry, PhotonAgedBone DensityCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedBone mineral densityDual-energy X-ray absorptiometryFacet joint osteoarthritisQuantitative computed tomography

Identifiers

PMID40715756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.