ArticleInternational journal of impotence research2026
A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy.
Article in International journal of impotence research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Response to comment on: A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy.International journal of impotence research · 2026Article
- Comment On: A novel circumcision technique for adult phimosis combining three techniques: a retrospective comparative study.International journal of impotence research · 2026Article
- Response to Comment on: A novel circumcision technique for adult phimosis combining three techniques: a retrospective comparative study.International journal of impotence research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rehabilitation of erectile function post-radical prostatectomy remains a great challenge in clinical practice. We aimed to develop a novel rat model suitable for investigating erectile dysfunction (ED) following nerve-sparing radical prostatectomy (NSRP) and to validate its applicability. Thirty-two male Sprague-Dawley rats were randomly assigned to undergo either a novel NSRP modeling procedure or sham surgery. The surgical protocol for the NSRP group included identification and dissection of the major pelvic ganglia and cavernous nerve, prostatectomy, and reconstruction of the lower urinary tract. Mean arterial pressure (MAP) and intracavernous pressure (ICP) were assessed at 1 and 2 weeks postoperatively. Subsequently, the penis tissues were collected for histopathological analyses. The results showed that rats in the NSRP group exhibited significantly lower maximum ICP/MAP ratios (0.39 ± 0.17 vs 0.77 ± 0.08, P < 0.0001) and areas under the ICP curve (2090.13 ± 1050.15 vs 4326.08 ± 1042.08, P = 0.0001) compared to the sham-operated group at 1 week postoperatively. By 2 weeks postoperatively, the NSRP group showed a significant improvement in both the maximum ICP/MAP ratio (0.73 ± 0.09 vs 0.39 ± 0.17, P < 0.0001) and the area under the ICP curve (3654.40 ± 679.28 vs 2090.13 ± 1050.15, P = 0.005) compared to the 1-week post-NSRP group. However, the area under the ICP curve in the NSRP group remained significantly lower than that in the sham-operated group at 2 weeks postoperatively (3654.40 ± 679.28 vs 5259.10 ± 951.48, P = 0.003). Similarly, histological staining suggested that smooth muscle atrophy and collagen deposition in the penis gradually improved over time post-NSRP. However, significant differences in the ratio of smooth muscle to collagen remained between the NSRP and sham-operated groups at 2 weeks postoperatively (0.22 ± 0.03 vs 0.27 ± 0.05, P = 0.011). In conclusion, this study established a novel rat model for investigating post-NSRP ED and validated its utility through erectile function monitoring and histological analysis. Further promising preclinical studies using this model are necessary to explore underlying mechanisms and evaluate the efficacy of treatments for post-NSRP ED.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.