Evidence map›Paper›PMID 40715740›Full record

ArticleCommunications chemistry2025

Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging.

Weiyuan Xu, Zheng Cai, Fabio Carniato, Yi Lu, Xinjian Ye, Xinhui Xiao, Jiao Xu, Gengshen Mo, Yinghui Ding, Yong Jian and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Design of bifunctional pyridinophane ligands as MnInorganic chemistry frontiers · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Weiyuan XuOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, China.
Zheng CaiDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fabio CarniatoDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Alessandria, Italy.
Yi LuDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinjian YeDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xinhui XiaoWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Jiao XuWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Gengshen MoWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Yinghui DingWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Yong JianWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Xinzhong RuanDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Fangfu YeOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, China. fye@iphy.ac.cn.
Carlos Platas-IglesiasUniversidade da Coruña, Centro Interdisciplinar de Química e Bioloxía (CICA) and Departamento de Química, Facultade de Ciencias, A Coruña, Spain. carlos.platas.iglesias@udc.es.ORCID http://orcid.org/0000-0002-6989-9654
Mauro BottaDipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Alessandria, Italy. mauro.botta@uniupo.it.ORCID http://orcid.org/0000-0003-4192-355X
Lixiong DaiWenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China. dailx@ucas.ac.cn.ORCID http://orcid.org/0000-0003-0983-2463

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) ECS00000036National Natural Science Foundation of China (National Science Foundation of China) 22075281National Natural Science Foundation of China (National Science Foundation of China) 22105201University of Chinese Academy of Sciences (Graduate University of Chinese Academy of Sciences) WIUCASQD2020008
6 · The paper itself

Abstract

Manganese(II) is considered a valuable alternative to gadolinium(III) in developing contrast agents (CAs) for magnetic resonance imaging (MRI). However, due to the labile nature of common Mn(II) complexes, designing ligands that enable stable and inert complexation is essential before clinical application. Mn(1,4-Et4DO2A) bearing four ethyl groups, is found to have a log K

Identifiers

PMID40715740
PMCPMC12297526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.