Evidence map›Paper›PMID 40715736›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2026

Implementation of an early intervention strategy for post hemorrhagic ventricular dilatation in preterm infants.

Diane Wilson, Sara Breitbart, Lee DiFonzo, Edmond Kelly, Yenge Diambomba, Dilkash Kajal, Kamini Raghuram, Sabrina Wong, Eugene Ng, Paige Church and 9 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Post-hemorrhagic ventricular dilatation: Comparison of management pathways among North American level IV NICUs.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Diane WilsonHospital for Sick Children, University of Toronto, Toronto, ON, Canada. diane.wilson@sickkids.ca.ORCID http://orcid.org/0000-0001-8350-5706
Sara BreitbartHospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0006-4162-2537
Lee DiFonzoMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Edmond KellyMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Yenge DiambombaMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Dilkash KajalMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Kamini RaghuramMount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Sabrina WongSunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0003-4969-6379
Eugene NgSunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.
Paige ChurchSunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.
Elizabeth AsztalosSunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.
Phyllis GlancSunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.
Mehmet CizmeciHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Rosanna PaisHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Jeffery TraubiciHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Lara M LeijserDepartment of Pediatrics, Section of Neonatology, University of Calgary, Calgary, AB, Canada.
Steven P MillerBC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Abhaya V KulkarniHospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Linh G LyHospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEvaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks' gestation. STUDY

designRetrospective, multi-center, observational study.

resultsOne hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).

conclusionInitiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.

Indexed as

Cerebral HemorrhageCerebral VentriclesInfant, Premature, DiseasesDilatation, PathologicFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureMaleRetrospective StudiesSpinal PunctureVentriculoperitoneal Shunt

Identifiers

PMID40715736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.