Evidence map›Paper›PMID 40715707›Full record

SynthesisApplied psychophysiology and biofeedback2025

The Efficacy of Virtual Reality-Based EEG Neurofeedback in Health-Related Symptoms Relief: A Systematic Review.

Lina Castanho, Diogo Vicente Martinho, Ana Cristina Saial, Bruna Raquel Gouveia, Élvio Rúbio Gouveia, Filipa Ribeiro

Abstract readSystematic Review
In one paragraph

Synthesis in Applied psychophysiology and biofeedback, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Digital Cognitive Rehabilitation Platforms for Older Adults in Portugal: A Systematic Review.International journal of environmental research and public health · 2026
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lina CastanhoFaculty of Health Sciences and Nursing, Catholic University of Portugal, Lisbon, Portugal. s-lccastanho@ucp.pt.ORCID 0009-0001-3226-3767
Diogo Vicente MartinhoLaboratory for Robotics and Engineering Systems (LARSyS), Interactive Technologies Institute (ITI), Funchal, Portugal.ORCID 0000-0003-0825-4032
Ana Cristina SaialLaboratory for Robotics and Engineering Systems (LARSyS), Interactive Technologies Institute (ITI), Funchal, Portugal.ORCID 0009-0008-3962-751X
Bruna Raquel GouveiaLaboratory for Robotics and Engineering Systems (LARSyS), Interactive Technologies Institute (ITI), Funchal, Portugal.ORCID 0000-0001-7706-190X
Élvio Rúbio GouveiaLaboratory for Robotics and Engineering Systems (LARSyS), Interactive Technologies Institute (ITI), Funchal, Portugal.ORCID 0000-0003-0927-692X
Filipa RibeiroFaculty of Health Sciences and Nursing, Catholic University of Portugal, Lisbon, Portugal.ORCID 0000-0001-7499-9062

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

EEG Neurofeedback is a noninvasive therapeutic modality that can potentially modify targeted aspects of brain function, considered promising for the treatment of neuropsychiatric disorders. Nevertheless, some limitations have considerable potential to compromise its efficacy, including the requirement for a high number of sessions, the repetition of therapeutic tasks, and the challenge in sustaining the objectives of these tasks. These limitations can induce a decline in system dynamism and user motivation. However, barriers can be overcome by integrating immersive virtual reality into a neurofeedback system to increase motivation, interest, and adherence through immersion and a sense of presence. This systematic review aimed to determine whether this combined treatment is effective in relieving symptoms related to general health. To conduct this search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, six electronic databases were accessed on January 26, 2024. Inclusion and exclusion criteria were defined to select the articles, and risk of bias and methodological quality assessment was conducted using the Mixed Methods Appraisal Tool and the CRED-nf checklist. A total of 24 trials were included, and according to Template for Developing Guidelines for the Evaluation of the Clinical Efficacy of Psychophysiological Interventions, the results showed that it was considered a probably efficacious treatment for attention and a possibly efficacious treatment for emotions, mood, pain, relaxation, impulsiveness, memory, self-esteem, creativity, empathy, meditation, and tiredness. Several methodological factors of the trials restrict the generalization of these findings and require caution in their interpretation, despite the promising results in future directions.

Indexed as

ElectroencephalographyNeurofeedbackOutcome Assessment, Health CareVirtual RealityHumansElectroencephalogramHealthImmersive virtual realityNeurofeedbackNeuromodulation

Identifiers

PMID40715707
PMCPMC12686002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.