Evidence map›Paper›PMID 40715704›Full record

ArticleScientific reports2025

Quantifying Spatial variation in environmental and sociodemographic drivers of leptospirosis in the Dominican Republic using a geographically weighted regression model.

Beatris Mario Martin, Benn Sartorius, Helen J Mayfield, Angela M Cadavid Restrepo, Behzad Kiani, Cecilia Jocelyn Then Paulino, Marie Caroline Etienne, Ronald Skewes-Ramm, Michael de St Aubin, Devan Dumas and 10 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Beatris Mario MartinFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia. beatris.martin@uq.edu.au.
Benn SartoriusFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia.
Helen J MayfieldFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia.
Angela M Cadavid RestrepoFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia.
Behzad KianiFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia.
Cecilia Jocelyn Then PaulinoMinistry of Health and Social Assistance, Santo Domingo, Dominican Republic.
Marie Caroline EtienneBrigham and Women's Hospital, Boston, MA, USA.
Ronald Skewes-RammMinistry of Health and Social Assistance, Santo Domingo, Dominican Republic.
Michael de St AubinBrigham and Women's Hospital, Boston, MA, USA.
Devan DumasBrigham and Women's Hospital, Boston, MA, USA.
Salome GarnierBrigham and Women's Hospital, Boston, MA, USA.
William DukePedro Henríquez Ureña National University, Santo Domingo, Dominican Republic.
Farah PeñaMinistry of Health and Social Assistance, Santo Domingo, Dominican Republic.
Gabriela AbdallaBrigham and Women's Hospital, Boston, MA, USA.
Lucia de la CruzMinistry of Health and Social Assistance, Santo Domingo, Dominican Republic.
Bernarda HenríquezMinistry of Health and Social Assistance, Santo Domingo, Dominican Republic.
Margaret BaldwinBrigham and Women's Hospital, Boston, MA, USA.
Adam KucharskiLondon School of Hygiene & Tropical Medicine, London, UK.
Eric J NillesBrigham and Women's Hospital, Boston, MA, USA.
Colleen L LauFaculty of Health, Medicine, and Behavioural Sciences, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia.

Funding

CDC HHS U01GH002238CGH CDC HHS U01 GH002238National Health and Medical Research Council 1109035
6 · The paper itself

Abstract

Spatial variation in drivers of leptospirosis transmission in the Dominican Republic is poorly understood. To inform targeted public health interventions, we aimed to characterise risk factors and drivers of transmission on a fine spatial scale. We analysed data from 2078 participants in two provinces, Espaillat and San Pedro de Macoris (SPM), collected from a 2021 cross-sectional survey. We used geographically weighted regression to quantify associations between leptospirosis seropositivity and spatial environmental and sociodemographic data. In Espaillat, higher odds of seropositivity were associated with exposure to freshwater (OR 6.51, ranging between 5.95 and 6.99), bare ground coverage above 1.44% (OR 3.70;3.49-3.92), river density surrounding the household at the highest quartile (OR 2.43;2.41-2.45) and average precipitation in the last five years at the highest quartile (2.57; 2.52-2.65). In SPM, rat exposure was associated with higher odds of seropositivity (OR 2.59;1.23-3.14). By identifying locally important drivers of transmission, our study provides evidence to support more tailored public health interventions to optimise the control and prevention of leptospirosis.

Indexed as

LeptospirosisAdolescentAdultAgedAnimalsCross-Sectional StudiesDominican RepublicFemaleHumansMaleMiddle AgedRisk FactorsSociodemographic FactorsSocioeconomic FactorsSpatial RegressionYoung AdultCaribbean regionRisk factorsSeroprevalence surveySpatial regressionZoonosis

Identifiers

PMID40715704
PMCPMC12297537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.