Evidence map›Paper›PMID 40715686›Full record

ArticleEJNMMI research2025

In vivo 3D myocardial membrane potential mapping in humans using PET/MRI.

Felicitas J Bijari, Paul Kyu Han, Thibault Marin, Wonil Lee, Yanis Chemli, Inna Gertsenshteyn, Ismaël B G Mounime, Yanis Djebra, Didi Chi, Marc D Normandin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Felicitas J Bijari *Yale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Paul Kyu Han *Yale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Thibault MarinYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Wonil LeeYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Yanis ChemliYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Inna GertsenshteynIndependent Researcher, Boston, MA, USA.
Ismaël B G MounimeYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Yanis DjebraYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Didi ChiYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Marc D NormandinYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA.
Chao MaYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA. chao.ma.cm2943@yale.edu.ORCID http://orcid.org/0000-0002-2016-8084
Georges El FakhriYale Biomedical Imaging Institute, Yale University School of Medicine, New Haven, CT, USA. georges.elfakhri@yale.edu.

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
PET/MR Mapping of Myocardial Membrane PotentialR01HL137230 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2017 to 2020
$3.3M
NHLBI NIH HHS R01HL137230NIBIB NIH HHS P41 EB022544NIBIB NIH HHS P41EB022544
6 · The paper itself

Abstract

backgroundThe mitochondrial membrane potential is a key biophysical parameter of mitochondrial function, which can be useful for the diagnosis and treatment monitoring of various cardiac diseases. We present a non-invasive PET/MR imaging method for 3D myocardial membrane potential mapping in humans.

resultsAn in vivo PET/MR imaging study was performed in three healthy subjects (1 male and 2 females; 48 ± 29 years old) under a study protocol approved by the local Institutional Review Board (IRB). Written informed consent was obtained from all subjects before participation in the study. The [

conclusionThe proposed method allows 3D myocardial membrane potential mapping in humans in vivo.

Indexed as

3DMagnetic resonance imagingMembrane potential mappingPositron emission tomography

Identifiers

PMID40715686
PMCPMC12297085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.