ArticleNature immunology2025
The transcription complex p52-ETS1 is essential for germinal center formation.
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.Immunology and cell biology · 2026Review
- ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation.Science advances · 2026Article
- BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition.Nature immunology · 2026Article
- A unique p52 NF-κB-ETS1 interaction ushers in a new paradigm of germinal center responses.Nature immunology · 2025Article
Corrections and comments
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Authors and funding
32 authors.
Funding
Abstract
The NF-κB family comprises five transcription factors (RELA, RELB, C-REL, NF-κB1 (p50) and NF-κB2 (p52)) that form homo- or heterodimers among themselves to regulate gene expression by binding DNA. Here we show that p52 activates transcription without directly binding DNA but as a heterotetrameric complex with ETS1, a transcription factor outside the NF-κB family. By generating a knock-in mouse model (Nfkb2
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Registered trials
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