Evidence map›Paper›PMID 40715615›Full record

ArticleScientific reports2025

White matter microstructure abnormalities in children experiencing neglect without other forms of maltreatment.

Natasha Y S Kawata, Takashi X Fujisawa, Kai Makita, Akiko Yao, Hidehiko Okazawa, Akemi Tomoda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natasha Y S KawataResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Takashi X FujisawaResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Kai MakitaResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Akiko YaoResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan.
Hidehiko OkazawaLife Science Innovation Center, University of Fukui, Fukui, 910-1193, Japan.
Akemi TomodaResearch Center for Child Mental Development, University of Fukui, Fukui, 910-1193, Japan. atomoda@u-fukui.ac.jp.

Funding

Japan Agency for Medical Research and Development JP20gk0110052Japan Society for the Promotion of Science 21K02352Japan Society for the Promotion of Science 22K13677Japan Society for the Promotion of Science 23K25644
6 · The paper itself

Abstract

Childhood maltreatment can disrupt brain development, leading to vulnerabilities in white matter (WM) microstructure, compromised brain integrity, and various psychiatric disorders. Among different forms of maltreatment, neglect is the most common; however, limited data exist on its specific impact on the brain. This study utilized diffusion tensor imaging to examine WM microstructure differences between neglected children without other types of maltreatment (Neglect, n = 21) and typically developing controls (TD, n = 106). Additionally, the study explored the relationship between WM microstructure alterations and psychosocial problems observed in neglected children. Neglected children exhibited larger axial diffusion (AD) in regions such as the right corticospinal tract (R.CST), right superior longitudinal fasciculus (R.SLF), and left cingulum (L.CG) compared to typically developing children. Increased AD in the R.CST, L.CG, and R.SLF was associated with conduct problems. These findings suggest that alterations in WM microstructure contributed to behavioral symptoms in neglected children.

Indexed as

Child AbuseWhite MatterCase-Control StudiesChildDiffusion Tensor ImagingFemaleHumansMaleChild maltreatmentDiffusion tensor imagingNeglect childrenTract-based spatial statistics

Identifiers

PMID40715615
PMCPMC12297236

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Registered trials

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