ArticleScientific reports2025
Comparative and pharmacological investigation of bEVs from eight Lactobacillales strains.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Selective Protein and Lipid Cargo Sorting into Extracellular Vesicles of Lacticaseibacillus paracasei subsp. paracasei.Probiotics and antimicrobial proteins · 2026Article
- Lactic acid bacteria-derived extracellular vesicles as postbiotic modulators of epithelial adhesion and barrier homeostasis: emerging perspectives.Frontiers in microbiology · 2026Article
- ExoBDNF Probiotic Supplementation Enhances Cognition in Subjective Cognitive Decline.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Bacterial extracellular vesicles (bEVs) have therapeutic potential by mimicking the effects of the microbiome. Here, we characterized bEVs from eight gram-positive Lactobacillales strains, evaluating their therapeutic potential. In primary characterization, Lactobacillus paracasei produced the largest bEVs (82.5 nm), while Lactococcus lactis yielded the highest number (3.2 × 10⁹ particles/mL). Lactobacillus plantarum had the highest protein content (0.124 pg/particle), while Lactobacillus salivarius had the greatest lipid content (16.3 µg/particle). Lipid content significantly influenced cytotoxicity in HEK293T cells (r² = 0.366, p = 0.037). Connectivity Map (CMap) analysis revealed correlations between bEVs from Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus acidophilus, and Streptococcus thermophilus and approved drugs for skin health. Experimentally, these bEVs enhanced collagen synthesis in fibroblasts by up to 1.25-fold (p < 0.001). Proteomic analysis identified distinct protein sets for each bEV. Further analysis demonstrated interaction networks between bEV proteins and human proteins that promote collagen production through the JAK-STAT, PI3K-AKT, and focal adhesion pathways. In conclusion, this study highlights the strain-specific characteristics and therapeutic potential of bEVs in promoting collagen production, presenting a novel approach to discovering new indications for bEVs in potential skin care applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.