ArticleMetabolomics : Official journal of the Metabolomic Society2025
Feasibility of amino acid profiling in long-term stored formalin-fixed paraffin-embedded colorectal neoplasia tissue.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMetabolic processes play a role in cancer development, with faecal amino acids emerging as potential biomarkers for colorectal neoplasia. While fresh frozen tissue is preferred for metabolomic analysis, formalin-fixed paraffin-embedded (FFPE) tissue is more widely available.
objectivesWe aimed to evaluate amino acid profiles in FFPE tissue across different stages of the adenoma-carcinoma sequence.
methodA panel of 20 amino acids was measured using liquid chromatography-tandem mass spectrometry.
resultsFourteen amino acids were detected, with proline elevated in colorectal carcinoma versus advanced (FC 2.33, p = 0.04) and non-advanced adenomas (FC 2.42, p = 0.02).
conclusionDespite analytical challenges, amino acid profiling in FFPE tissue is feasible.
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