ArticleCommunications biology2025
Pericyte-mediated regulation of angiogenesis during cutaneous wound healing in adult zebrafish.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction.The journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pericytes are mural cells that wrap small caliber vessels, playing a crucial role in stabilizing vascular structure. Upon induction of angiogenesis, pericytes were thought to detach from the vessel wall, thereby facilitating the sprouting of endothelial cells (ECs). However, the precise roles of pericytes in regulating angiogenesis still remain elusive. Here, we demonstrate, by performing live-imaging of adult zebrafish, that pericytes actively regulate angiogenesis during wound healing. We generated a zebrafish line which enables the conditional ablation of mural cells, including pericytes, and analyzed cutaneous wound angiogenesis. Loss of pericytes significantly increased the number of sprouting events of ECs and promoted their proliferation, resulting in the formation of dense and disorganized blood vessel networks. Furthermore, in the absence of pericytes, the injured vessels showed abnormal vessel elongation, thereby generating ectopic vascular networks. These results suggest that pericytes play an active role for generating functional blood vessels during wound angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.