ArticleInternational journal of obesity (2005)2025
Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus).
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveCharacterize the effects of obesity on common marmoset glucose metabolism and develop predictive markers of glucose metabolism dysfunction.
methodsBody size, weight, lean mass, fat mass, %fat, resting energy expenditure (REE), and glycosylated hemoglobin (HbA1c) were measured on 51 adult marmosets. Physical activity was assessed using actimeter collars (n = 50). A body mass-per-length parameter (BML) was constructed. Animals were classified as without obesity or with obesity (%fat >10%) and by the age they obtained maximum weight (Maxwt). Correlation, MANOVA, and binary logistic regression were used to examine relationships between parameters; path analysis to explore directional relationships.
resultsBody fat and BML were correlated (r = 0.565, p < 0.001). Both were correlated with HbA1c (r = 0.658; r = 0.764, p < 0.001). Activity was negatively correlated with %fat and REE (r = -0.437, p = 0.002; r = -0.473, p < 0.001). REE was correlated with %fat, BML, and HbA1c (r > 0.5, p < 0.001). Marmosets with obesity were more likely to have elevated HbA1c (>5.7%; odds ratio = 8.25, p = 0.003). BML above 3.4 g/mm predicted obesity (OR = 6.25 [95% CI 1.62-24.02], p = 0.008) and high HbA1c (OR = 29.47 [95% CI 6.21-139.72], p < 0.001). Early Maxwt predicted increased fat mass (F = -0.476, p = 0.015) and high %fat (F = -0.084, p = 0.014).
conclusionBoth %fat and BML were markers for high HbA1c. Early maximum adult weight predicts increased adiposity and risk of glucose dysfunction.
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