Evidence map›Paper›PMID 40715571›Full record

ArticleScientific reports2025

Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank.

Gana Odeh, Mohammed Alili, Roa Hamshari, Ahmad Saabna, Rami Zagha, Mahmoud Draidi, Safa' Bushnaq, Suheir Ereqat, Basma Damiri

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Gana Odeh *Department of Medicine, An-Najah National University, Nablus, Palestine.
Mohammed Alili *Department of Medicine, An-Najah National University, Nablus, Palestine.
Roa HamshariDepartment of Medicine, An-Najah National University, Nablus, Palestine.
Ahmad SaabnaDepartment of Medicine, An-Najah National University, Nablus, Palestine.
Rami ZaghaDepartment of Pathology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Mahmoud DraidiDepartment of Medicine, An-Najah National University, Nablus, Palestine.
Safa' BushnaqMolecular Genetics Laboratory, An-Najah National University Hospital, Nablus, Palestine.
Suheir EreqatBiochemistry and Molecular Biology Department, Faculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Basma DamiriFaculty of Medicine and Health Sciences, Physiology, Pharmacology, and Toxicology Division, An-Najah National University, P400, PO Box 7, Nablus, Palestine. bdamiri@najah.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycythemia is a hematological condition characterized by an elevated red blood cell (RBC) mass that exceeds the normal range for a specific age and gender; it can be classified as either primary or secondary. This study aimed to estimate the prevalence of primary and secondary polycythemia among adult blood donors in the West Bank and characterize potential risk factors. This cross-sectional study included 674 adult Palestinian male blood donors, aged 18 to 62 years, at An-Najah National University Hospital. Data were collected through face-to-face interviews. Eligible donors underwent complete blood count (CBC) analysis, and samples meeting the latest World Health Organization (WHO) diagnostic criteria for polycythemia, hemoglobin > 16.5 g/dL or hematocrit > 49% in men, were sent for DNA sequencing. Among the participants, 16.6% met the diagnostic criteria for polycythemia; however, none had the JAK2 p.V617F mutation, indicating a potential lack of polycythemia vera (PV). Risk factor analysis revealed an increased risk of polycythemia in moderate (p = 0.039, OR 2.223, [95% CI 1.041-4.746]), heavy cigarette smoking (p = 0.008, OR 2.301, [95% CI 1.246-4.249]), and heavy waterpipe smoking (p ≤ 0.001, OR: 5.019, [95% CI 2.364-10.653]), whereas heavy coffee consumption had a protective effect against polycythemia (p = 0.013, OR 0.444 [95% CI 0.234-0.843]). The absence of the JAK2 p.V617F mutation among participants suggests that secondary polycythemia predominance is driven by smoking and other modifiable lifestyle factors. These findings emphasize the importance of public health efforts focused on lifestyle modification to reduce the risk of polycythemia.

Indexed as

Blood DonorsPolycythemiaAdolescentAdultArabsCross-Sectional StudiesHumansJanus Kinase 2MaleMiddle AgedMiddle EastPrevalenceRisk FactorsYoung AdultJAK2 protein, humanJanus Kinase 2Blood donationHemoglobinJAK2 mutationPolycythemiaTobacco smokingWest bank

Identifiers

PMID40715571
PMCPMC12297454

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