ArticleLasers in medical science2025
A novel chlorine derivative ShengTaiBuFen mediated photodynamic therapy on a mouse wound model infected with methicillin-resistant Staphylococcus aureus.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is the most common and difficult-to-treat pathogen in chronic wounds. In this study, a novel derivative of chlorin, ShengTaiBuFen (STBF), was used as a photosensitiser to investigate the effect of STBF mediated photodynamic therapy (STBF-PDT) on MRSA-infected ulcers. Appropriate incubation time and concentration parameters were initially explored to evaluate the anti-MRSA performance of STBF-PDT in vitro. An infected mouse skin ulcer model was further established to assess the antibacterial ability of STBF-PDT on MRSA in ulcers and the ultimate effect on ulcers. Our data showed that the antibacterial activity of STBF-PDT against planktonic MRSA was strongest at 25 µM concentration in a light dose-dependent way, and MRSA strains were completely eliminated at 120 J/cm
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