Evidence map›Paper›PMID 40715529›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025

Challenging the neutral axis: 15-year results of under-corrected varus in total knee arthroplasty.

Amyn M Rajani, Clevio Desouza, Vishal Kulkarni, Anmol R S Mittal

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Amyn M RajaniOAKS Clinic, 707, Panchsheel Plaza, N S Patkar Marg, next to Dharam Palace, Gamdevi, Mumbai, Maharashtra 400007, Mumbai, India. dramrajani@gmail.com.
Clevio DesouzaOAKS Clinic, 707, Panchsheel Plaza, N S Patkar Marg, next to Dharam Palace, Gamdevi, Mumbai, Maharashtra 400007, Mumbai, India. ceviod@gmail.com.
Vishal KulkarniOAKS Clinic, 707, Panchsheel Plaza, N S Patkar Marg, next to Dharam Palace, Gamdevi, Mumbai, Maharashtra 400007, Mumbai, India.
Anmol R S MittalOAKS Clinic, 707, Panchsheel Plaza, N S Patkar Marg, next to Dharam Palace, Gamdevi, Mumbai, Maharashtra 400007, Mumbai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWhile total knee arthroplasty (TKA) is effective for managing end-stage tricompartmental osteoarthritis, up to 30% of patients report dissatisfaction due to functional limitations. There is increasing interest in whether maintaining slight residual varus alignment may better replicate native knee kinematics and improve outcomes.

methodsThis retrospective, single-center study evaluated 123 knees in 77 patients who underwent primary TKA between 2008 and 2010. The surgical aim was mild under-correction of varus deformity. Postoperative limb alignment was classified as residual varus (1°-3°), neutral (0°), or mild valgus (1°-2°). Clinical and radiological evaluations were performed at a mean follow-up of 15.5 years. Outcome measures included KOOS, KSS, FJS-12, VAS for pain/satisfaction, range of motion, and the ability to kneel or sit cross-legged. Radiographs assessed mechanical alignment and implant integrity.

resultsResidual varus alignment (1°-3°) was achieved in 78.9% of knees. KOOS, KSS, and FJS-12 scores improved across all groups, with the varus group showing slightly higher final scores (KOOS: 92.8 ± 2.8) compared to neutral (92.0 ± 2.6) and valgus (91.4 ± 3.1), though not statistically significant. Radiographs showed no loosening or failure. Activities such as kneeling and cross-legged sitting were better preserved in the varus group.

conclusionAt 15-year follow-up, patients with mild residual varus alignment demonstrated excellent functional outcomes and implant survival, with trends toward better satisfaction and cultural functionality. Mild under-correction in varus knees appears safe and may support more personalized alignment strategies.

Indexed as

Arthroplasty, Replacement, KneeBone MalalignmentKnee JointOsteoarthritis, KneeAgedAged, 80 and overFemaleFollow-Up StudiesHumansKnee ProsthesisMaleMiddle AgedPatient SatisfactionRadiographyRange of Motion, ArticularRetrospective StudiesAlignment strategyCultural activitiesImplant survivalKOOSLong-term outcomesResidual varusTotal knee arthroplasty

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.