Evidence map›Paper›PMID 40715528›Full record

SynthesisScientific reports2025

Core exercises for performance, pain, and Lower-limb biomechanics in individuals with ACL-Reconstruction: A systematic review with Meta-analysis of randomized control trials.

Mostafa Jalili Bafrouei, Seyed Hamed Mousavi, Fateme Khorramroo, Johannes Zwerver

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mostafa Jalili BafroueiDepartment of Sport Injuries and Biomechanics, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
Seyed Hamed MousaviDepartment of Sport Injuries and Biomechanics, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran. musavihamed@ut.ac.ir.
Fateme KhorramrooDepartment of Sport Injuries and Biomechanics, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.
Johannes ZwerverSpots Valley, Department of Sports Medicine, Gelderse Vallei Hospital, Ede, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Core exercises (CE) are often included in rehabilitation programs following anterior cruciate ligament reconstruction (ACLR) to enhance recovery and functional outcomes. This systematic review aimed to evaluate the impact of CE on performance outcomes, pain management, and lower-limb biomechanics in individuals after an ACLR. A comprehensive search was conducted in PubMed, Web of Science, Scopus, and Embase from inception to May 3, 2025. Two independent reviewers screened studies reporting the effects of CE on pain and function in individuals with ACLR. The primary outcomes were: pain intensity, measured using the Visual Analogue Scale (VAS), Knee injury and Osteoarthritis Outcome Score-Pain subscale (KOOS-Pain), and Hospital for Special Surgery (HSS) score. functional outcomes, including self-reported function (International Knee Documentation Committee [IKDC] score, Lysholm score, Tegner activity scale), performance-based tests (single-leg hop tests), and range of motion (ROM). Lower-limb biomechanics, assessed via gait analysis, KT-1000 arthrometer, and joint reaction force analysis. The methodological quality of included studies was assessed using the Physiotherapy Evidence Database (s) scale. Meta-analysis was conducted using a random-effects model, and mean differences with 95% confidence intervals (CIs) were calculated in RevMan 5.4. Ten studies with a total of 463 participants were included. The meta-analysis suggested strong evidence of non-significant changes in VAS, KOOS-pain, and HSS scores between the CE and the traditional exercise groups. The meta-analysis demonstrated strong evidence of significant improvement in IKDC score and hop test score, along with moderate evidence of significant improvement in Lysholm and Tegner scores between the CE and the traditional exercise groups. The result of biomechanical outcomes revealed limited improvements in gait parameters. CE may offer significant benefits for functional performance, especially in IKDC scores, when combined with lower-limb strengthening programs, but their effects on pain relief and biomechanics are less consistent. Future research should focus on standardized protocols and follow-up periods to further explore the role of CE in ACLR rehabilitation.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionExercise TherapyLower ExtremityPainBiomechanical PhenomenaHumansPain ManagementPain MeasurementRandomized Controlled Trials as TopicRange of Motion, ArticularACLFunctionInjuryKneeROMStabilityTrunk

Identifiers

PMID40715528
PMCPMC12297383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.