Evidence map›Paper›PMID 40715486›Full record

ArticleGene therapy2025

AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs.

Theodore Dimitrov, Vikas Munjal, Allison O'Brien, Matthew T Rocco, Ahmad Karkhah, Kaya E Ceyhan, Daniel Prevedello, Lluis Samaranch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theodore Dimitrov *Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Vikas Munjal *Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Allison O'BrienDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Matthew T RoccoDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Ahmad KarkhahDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Kaya E CeyhanDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Daniel PrevedelloDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
Lluis SamaranchDepartment of Neurological Surgery, The Ohio State University, Columbus, OH, USA. lluis.samaranch@osumc.edu.ORCID 0000-0001-8151-473X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the potential of adeno-associated virus serotype 9 (AAV9) to deliver therapeutic genes directly into the memory circuit throughout the olfactory bulb (OB), a critical memory and sensory processing region. Using convection-enhanced delivery (CED) of AAV9 encoding green fluorescent protein (GFP), we mapped the extensive neural connectivity from the OB to key memory-related brain regions, including the entorhinal cortex (EC) and hippocampus. Our findings reveal significant transduction of neural pathways and underscore the potential of targeting the OB connectome for therapeutic interventions in progressive neurodegenerative disorders such as Alzheimer's disease or mild cognitive impairment. Targeting the OB connectome will pave the way for new therapeutic strategies to preserve neuronal function and slow the progression, offering a promising avenue beyond symptomatic relief to address the underlying mechanisms of the disease.

Indexed as

DependovirusMemoryOlfactory BulbAnimalsConnectomeConvectionEntorhinal CortexGenetic TherapyGenetic VectorsGene Transfer TechniquesGreen Fluorescent ProteinsHippocampusHumansMaleMiceTransduction, GeneticGreen Fluorescent Proteins

Identifiers

PMID40715486
PMCPMC12714586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.