ArticlePediatric research2026
Imposed work of breathing of 16 neonatal CPAP-devices using different mechanisms of CPAP generation.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesFailure of continuous positive airway pressure (CPAP) in preterm infants may result from respiratory exhaustion, potentially also evoked by the CPAP device's imposed work of breathing (iWOB). This study investigated in-vitro the iWOB of 16 CPAP-devices in four simulated neonatal scenarios with focus on the impact of different mechanisms of CPAP-generation.
methodsA neonatal lung model and 3D-printed nasopharyngeal dummies (representing a 1000 g preterm and a 3000 g term infant, settings: preterm/term: V
resultsDuring 9300 simulated breaths, iWOB differed widely across investigated devices. The lowest inspiratory iWOB were observed in Bubble CPAP, variable-flow devices and constant-flow devices with turbine (0.04/0.15-0.17 mJ/breath for preterm/term model resp. 0.07/0.24-0.33 mJ/breath). Devices with mechanical regulation and with constant resistance require higher inspiratory effort and are therefore not relevant in the low iWOB group. The highest iWOB (0.41/2.92 mJ/breath at 5 cmH
conclusionsThe magnitude of iWOB varied considerably between devices. This should be considered, to optimize non-invasive respiratory support in neonates. IMPACT: This bench study detected differences in the imposed work of breathing (iWOB) between 16 different CPAP devices. In addition to existing literature, the present study contributes to a more comprehensive understanding of iWOB and the influence of CPAP generation due to the large number of CPAP devices investigated. If the identified differences are confirmed in clinical practice, this could streamline decision-making in CPAP device selection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.