ArticleCommunications biology2025
Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination.
Xinyi Wu, Qian Zhang, Chang Li, Shuning Zhuang, Hongyuan Liu, Xue Jiao, Shidou Zhao, Yingying Qin, Ting Guo
Abstract read
In one paragraphArticle in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Xinyi Wu *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Qian Zhang *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Chang Li *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Shuning ZhuangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Hongyuan LiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Xue JiaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-2936-2166 Shidou ZhaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0003-4722-1575 Yingying QinState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-0319-7799 Ting GuoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China. gtlyp2008@126.com.ORCID http://orcid.org/0000-0002-6354-238X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The DNA damage response plays a pivotal role in ovarian aging. Breast cancer susceptibility gene 2 (BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variants have been identified in patients with premature ovarian insufficiency (POI). However, the underlying molecular mechanisms are not well understood. Using a viable mouse model, Brca2
Indexed as
BRCA2 ProteinHomologous RecombinationMeiosisPrimary Ovarian InsufficiencyAllelesAnimalsDisease Models, AnimalDNA Breaks, Double-StrandedFemaleHumansMiceOocytesRad51 RecombinaseBRCA2 ProteinBRCA2 protein, mouseRad51 Recombinase
Identifiers
PMID40715368
PMCPMC12297597
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